Abstract：There are many types of intestinal microbes, which form a complex intestinal microecosystem. The intestinal microecosystem co-exists with the host and affects the hosts health, and it is known as the "second genome" of human beings. Intestinal microecological imbalance is closely related to the occurrence and development of malignant tumors. The current research results show that changes in the diversity and abundance of intestinal microorganisms including bacteria, fungi and viruses are related to tumorigenesis and its development. These microorganisms can affect tumors by regulating host inflammation and immunity, participating in material metabolism, and disrupting gene stability process. However, there are significant differences in the results of various studies, which may be related to various factors such as inconsistent research methods and the complexity of intestinal microorganisms. Regulation of intestinal microecology through diet therapy, supplementation of probiotics or missing bacteria, and application of antibiotics may become new methods for tumor prevention and treatment. This article summarizes the current research progress on the relationship between intestinal microecology and the occurrence and development of malignant tumors. Also, it points out some challenges and possible solutions for intestinal microbiological research in the field of oncology, as well as the new direction of tumor prevention and treatment targeting intestinal microecology in the future. The review aims to clarify the ideas for further tumor-microbial research and accelerate the clinical transformation of the research results, and provide new strategies for tumor diagnosis and treatment.
陈菲，梁婷婷，吕铮，李薇，崔久嵬. 肠道微生态与肿瘤发生和发展关系的研究进展[J]. 肿瘤代谢与营养电子杂志, 2020, 7(1): 7-12.
Chen Fei, Liang Tingting, Lyu Zheng, Li Wei, Cui Jiuwei. Research progress on the relationship between intestinal microecology and tumorigenesis and development. Electron J Metab Nutr Cancer, 2020, 7(1): 7-12.
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