恶性肿瘤患者低相位角与营养风险和住院时间相关性研究

doi:10.16689/j.cnki.cn11－9349/r.2019.04.012

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摘要目的探讨恶性肿瘤患者相位角与营养风险和住院时间相关性。方法利用生物电阻抗分析对2017年10月至2018年9月在河北医科大学第一医院接受治疗的259例恶性肿瘤患者进行人体成分检测、应用营养风险筛查2002和患者主观整体营养评估进行营养风险筛查和评估、同时收集患者血清ALB指标和住院时间。结果正常相位角组患者的BMI、ICW、FFM、SMM、BCM、蛋白质等均高于低相位角组（P<0.05）；正常相位角组与低相位角组男性患者ICW、FFM、SMM、BCM、蛋白质等均高于女性患者（P<0.05）；相位角与营养风险筛查2002评分（r=－0.346，P<0.05）、患者主观整体营养评估（r=－0.393，P＜0.05）呈负相关，与血清ALB值呈正相关（r=0.363，P<0.05）；与正常相位角组患者相比，低相位角组营养风险更高，计算相关风险比发现，按营养风险筛查2002评价营养不良分组，发现存在营养风险（OR=3.7，95%CI=1.8～7.7），按PG-SGA评估分组，结果显示中度风险（OR=4.5，95％CI=2.1～9.4），重度风险（OR=12.6，95％CI=5.1～31.3），按血清ALB值分组，ALB<40g/L（OR=3.7，95％CI=2.1～6.4）（P<0.05）；与正常相位角组患者相比，低相位角组住院时间较长，住院时间≥14d（OR=1.9，95％CI=1.0～3.3）（P<0.05）。结论低相位角与营养风险和住院时间密切相关。与正常相位角患者相比，低相位角患者存在营养风险高，住院时间延长。因此对肿瘤患者进行相位角测量有助于快速判断其是否存在营养风险，为及时进行营养干预的实施提供了客观依据，利于患者疾病控制与好转。

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关键词 ：相位角, 营养风险筛查2002, 患者主观整体营养评估, 白蛋白, 住院时间

Abstract：ObjectiveTo explore the association between phase angle （PA） and nutritional risk and hospital length of stay in patients with malignant tumors. Methods We selected 259 patients with malignant tumors who were treated at the First Hospital of Hebei Medical University from October 2017 to September 2018 and used bioelectrical impedance analysis （BIA） for body composition testing to them. We chose nutritional risk screening 2002 （NRS 2002） for nutritional risk screening and patient-generated subjective global assessment （PG-SGA） for nutritional risk assessment to patients with malignant tumors, while collecting patients serum albumin （ALB） and hospitalization time. ResultsWe found that the BMI, ICW, FFM, SMM, BCM and protein of patients with malignant tumors in the normal PA group are higher than those in the low PA group （P<0.05）. The ICW, FFM, SMM, BCM and protein of male patients with malignant tumors in normal PA group and low PA group are higher than those in females （P<0.05）. The PA have an obviously negative correlation with NRS 2002 （r=－0.346，P<0.05） and PG-SGA （r=－0.393，P＜0.05）, meanwhile PA have a positive correlation with serum albumin （r=0.363，P<0.05） in evidence. Compared with the patients with malignant tumors in normal PA group, the patients in the low PA group are more likely to have nutritional risk. We calculate a serious of odds ratio （OR） and the results show that patients with malignant tumors who have nutritional risk （OR=3.7,95%CI=1.8~7.7） in the malnutrition group evaluated by NRS 2002 score, while moderate nutritional risk （OR=4.5, 95% CI=2.1~9.4） and severe nutritional risk （OR=12.6, 95% CI=5.1~31.3） by PG-SGA, grouped by serum albumin shows that serum albumin<40g/L （OR=3.7, 95% CI=2.1~6.4）. Compared with the normal PA group patients, the low PA group patients have a longer hospital stay, and the hospitalization time is greater than or equal to 14 days （OR=1.9, 95% CI=1.0~3.3）（P<0.05）. ConclusionLow PA is closely related to nutritional risk and hospital length of stay in patients with malignant tumors. Compared with normal PA patients, patients with low PA have higher nutritional risk and longer hospital length of stay. Therefore, to get PA of malignant tumor patients is helpful to quickly judge whether there is nutritional risk in them, which provides an objective basis for the implementation of nutritional intervention in time, and is conducive to disease control and improvement of patients.

Key words： Phase angle Nutritional risk screening 2002 Patient-generated subjective global assessment Albumin Hospitalization time

基金资助:河北省重点研发计划项目健康医疗与生物医药专项（182777127D）
河北医科大学创新性实验计划项目（USIP2019260）

通讯作者: 李增宁，电子邮箱：lizengning@126.com

引用本文:

宋世明，杜红珍，李增宁. 恶性肿瘤患者低相位角与营养风险和住院时间相关性研究[J]. 肿瘤代谢与营养电子杂志, 2019, 6(4): 451-456.
SONG Shi-ming, DU Hong-zhen, LI Zeng-ning. Study on the correlation between low phase angle and nutritional risk and hospitalization time in patients with malignant tumor. Electron J Metab Nutr Cancer, 2019, 6(4): 451-456.

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