Abstract：Abstract: Objective This study was designed to explore the preparation of bovine serum albumin nanoparticles and its application and metabolism in nude mice bearing human breast cancer cell line SK-BR3 in vivo. Methods The distribution and metabolism of albumin nanoparticles with the mark of 125I prepared by the method of phacoemulsification-chemical cross-linking were discussed in nude mice bearing human breast cancer cell line SK-BR3 in vivo. Results The average size of bovine serum albumin nanoparticles prepared is 34 nm, 90% of which is less than 38 nm. Bovine serum albumin nanoparticles and bovine serum albumin had obvious targeting at tumor, liver, stomach, intestinal and other organs, and the difference was significant (P<0.05), but less in brain with no obvious targeting. Conclusions Bovine serum albumin nanoparticles with such good targeting at tumor, liver,gastrointestinal organs may be an ideal carrier of drug deliver in central nervous system, which can be produced to be a higher targeting nanoparticles with further surface modification.
2014, Vol. 1 
