中性粒细胞与肿瘤复杂相关性的研究进展

doi:10.16689/j.cnki.cn11－9349/r.2019.02.003

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摘要中性粒细胞具有多重功能，包括分泌趋化因子和细胞因子的能力，形成细胞外陷阱以及对肿瘤增殖与转移进行调控的能力。有关其可塑性与异质性的研究表明，循环中性粒细胞与肿瘤相关中性粒细胞在肿瘤增殖与转移调控中的作用十分显著，并表现为双重作用。一方面，中性粒细胞能够促进肿瘤炎症、肿瘤细胞增殖与侵袭以及肿瘤血管的生成，并且能够通过抑制T细胞的活性，促进肿瘤免疫逃避。另一方面，中性粒细胞能够促进T细胞抗肿瘤效应，并且可以通过产生相应的细胞因子参与肿瘤抑制。此前，肿瘤相关中性粒细胞的研究多以动物模型为依据，近年来，有研究进一步指出了对人类肿瘤相关中性粒细胞的认识，并探讨了中性粒细胞成为肿瘤免疫治疗新靶点的可能性。目前，对于肿瘤与中性粒细胞复杂相关性的多项研究表明，细胞治疗对肿瘤生物学的认识、肿瘤标志物的开发以及肿瘤的治疗均具有重要作用。本文就中性粒细胞与肿瘤复杂相关性研究的进展作一综述。

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	郭菲菲
	崔久嵬

关键词 ：循环中性粒细胞, 肿瘤相关中性粒细胞, 肿瘤靶向治疗

Abstract：Neutrophils have multiple functions， including the ability to secrete chemokines and cytokines， the ability to form extracellular traps， antigen presentation， and the ability to regulate tumor proliferation and metastasis. The findings of neutrophil plasticity and heterogeneity suggest that circulating neutrophils and tumor-associated neutrophils play a significant role in the regulation of tumor proliferation and metastasis. On the one hand， neutrophils promote tumor inflammation， tumor cell proliferation and invasion， and tumor angiogenesis. Besides， it can promote tumor immune escape by inhibiting the activity of cytotoxic T cells. On the other hand， neutrophils can promote the antitumor effect of T cells and participate in tumor inhibition by producing corresponding cytokines. Previously， the study of tumor-associated neutrophils was based on animal models. Recently， some studies have further pointed out the understanding of human tumor-associated neutrophil， and explored the possibility of neutrophils becoming a new target of tumor immunotherapy. At present， many studies on the complex relationship between tumors and neutrophils have shown that cell therapy plays an important role in the understanding of tumor biology， the development of tumor markers and the treatment of tumor. This article reviews the progress in the study of the relationship between neutrophils and tumor complexity.

Key words： Circulating neutrophils Tumor-associated neutrophils Tumor targeting therapy

基金资助:吉林省科技厅重点实验室建设项目（20170622011JC）；吉林省科学技术厅科技发展计划项目吉林省重点实验室专项（20180101009JC）；吉林省发展和改革委员会省级产业创新专项资金项目（2017C022）；吉林省科技厅科技发展计划项目（20190303146SF）；吉林省财政厅（2018SCZWSZX-010）

通讯作者: 电子邮箱：cuijw@jlu.edu.cn

引用本文:

郭菲菲，崔久嵬. 中性粒细胞与肿瘤复杂相关性的研究进展[J]. 肿瘤代谢与营养电子杂志, 2019, 6(2): 167-171.
GUO Fei-fei， CUI Jiu-wei. Progress in the study of the complex correlation between neutrophil and tumor. Electron J Metab Nutr Cancer, 2019, 6(2): 167-171.

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