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| Cannabidiol in tumor therapy |
| 1Zhou Ruiyi ，1Wu Xiaocong ，2Lei Yi ，1Sun Jiaxue ，1，2Xu Yu ，1，3Wang Kunhua |
| 1NHC Key Laboratory of Drug Addiction Medicine Kunming Medical University Kunming 650032 Yunnan China
2Department of
Gastrointestinal and Hernia Surgery the First Affiliated Hospital of Kunming Medical University Kunming 650032 Yunnan
China
3Yunnan University Kunming 650032 Yunnan China |
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Abstract Cannabidiol CBD is the main component of cannabis extract which is a non - psychoactive substance with non -
addictive low toxicity and high safety. CBD has shown unique advantages in tumor therapy and is being used on refractory
epilepsy. Its mechanisms include as follows. ① Inducing cell cycle arrest and inhibiting tumor cell proliferation. ② Promoting tumor
cell apoptosis through increasing ROS levels in tumor cells inducing mitochondrial dysfunction regulates Bcl-2 family proteins and
inhibiting IAP family protein function. ③ Inhibiting tumor cell migration and invasion. ④ In conjunction with other anti - cancer
therapies to exert a stronger anti-tumor effect. ⑤Relieve tumor-related symptoms such as pain anxiety and depression. ⑥It may play
a role in regulating the tumor microenvironment. CBD has shown good anti - tumor properties in various tumor treatments and is
expected to be used as a new tumor treatment drug in clinical practic. At present clinical trials related to CBD and cancer treatment
mainly focus on analgesic treatment for patients with advanced tumors and its direct therapeutic effect still needs further clinical trials.
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Received: 05 August 2022
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