|
|
|
Abstract Objective To explore the correlation between sarcopenia and tumor clinical stage characteristics adverse reactions
after chemotherapy and peripheral blood inflammatory indexes. Moreover the correlation between appendicular skeletal mass index
ASMI and the patient-generated subjective global assessment PG-SGA for the assessment of patient nutritional status were also be
analyzed. Method The clinical data of 125 patients with advanced gastric cancer in the First Affiliated Hospital of University of Science
and Technology of China Western District from January 2019 to February 2022 were collected. Pearson analysis was carried out to
analyze the correlation between ASMI and PG-SGA score. Result Among the 125 patients the incidence of sarcopenia was 43. 2% 54
of 123 patients . The sarcopenia group was significantly older and the incidence of grade Ⅲ/ Ⅳ adverse reactions after chemotherapy
was higher In addition the sarcopenia group showed lower BMI but higher PG-SGA score and NLR neutrophil-to-lymphocyte
ratio NLR P <0. 05 . Univariate analysis and multivariate analysis showed that age PG-SGA score grade Ⅲ/ Ⅳ adverse reaction
after chemotherapy and NLR were independent risk factors for sarcopenia P < 0. 05 . There was a significant negative correlation
between ASMI and PG-SGA score r = - 0. 38 P < 0. 001 . Conclusion Advanced age the occurrence of adverse reactions after
chemotherapy and the systemic inflammatory state of patients are closely related to the occurrence of sarcopenia in advanced gastric
cancer. ASMI and PG-SGA have a good correlation in the evaluation of nutritional status of patients.
|
|
Received: 03 August 2022
|
|
|
|
|
|
