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| Development and application of postbiotics |
| 1Shi Jiangmin ,1Shi Dibang ,1Xue Yilang ,2Luo Ming ,3Ruan Chuanxian ,3Ruan Weidi ,3Wang Fangyan |
| 1Department of Gastrointestinal Surgery The Second Affiliated Hospital of Wenzhou Medical University Wenzhou 325000 Zhejing China
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The college of Basic Medical Sciences of Wenzhou Medical University Wenzhou 325035 Zhejiang China
3Microbial Reserch Institute Japan Kyowa Industrial Co. Ltd. Tokyo 1710014 Japan |
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Abstract Since Katerina Tsilingiri proposed the concept of postbiotics in 2013 its definition has undergone several changes.
Recently the International Scientific Association for Probiotics and Prebiotics ISAPP issued a widely-accepted definition Postbiotics is a preparation of inanimate microorganisms and / or their components that confers a health benefit on the host . This paper reviews
its preparation techniques biological activities and characteristic advantages. In recent years based on conventional postbiotic preparation techniques new technologies such as technical association pasteurization supercritical carbon dioxide and pulsed electric field
have emerged furthemore the postbiotic preparation techniques of symbiotic flora have become mature and the related products exhibited certain efficacy in clinical trial. A lot of literatures confirm that postbiotics enhance health in a multidimensional manner. This review highlights the functional properties of postbiotics such as regulating intestinal flora protecting gastrointestinal mucosa improving
immune homeostasis including improving body immunity and preventing allergic diseases inhibiting inflammatory response antioxidant response inhibiting tumor cell proliferation assisting conventional tumor treatment treating neuropsychiatric diseases and regulating metabolism including hypoglycemia hypolipidemia etc. we also tried to elaborate the possible mechanisms on medical application and to share with the readers. Compared with active probiotics postbiotics have more obvious advantages in terms of stability
safety colonization free and applicability which make them show more significant potential for development and prospects for application.
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