|
|
|
| Progress in the study of the relationship between fatty acid metabolism and chemotherapy resistance in glioblastoma |
| Xu Linzong, Sun Xiaolin, Zhang Zhanyu, Li Xiaomei |
| Tumor Research and Therapy Center Shandong Provincial Hospital Shandong University Jinan 250021 Shandong China |
|
|
|
|
Abstract Cancer cells undergo significant changes in metabolic patterns during carcinogenesis involving many aspects of sugar
lipid amino acid and nucleic acid metabolism. It is the abnormal activation and reprogramming of these important metabolic pathways
that endow cancer cells with unlimited proliferative potential and malignant biological features. Metabolic reprogramming in glioblastoma
is also one of the distinctive features of tumorigenesis in which fatty acid metabolism also plays an important role in energy storage
cell proliferation synthesis of important signaling molecules and chemoresistance. The treatment of glioblastoma still faces great challenges and resistance to the standard therapeutic agent temozolomide is one of the treatment difficulties. Chemoresistant glioblastoma
cells exhibit more active levels of fatty acid metabolism compared to primary glioblastoma cells. Alterations in intra- and extracellular
metabolites that accompany cancer-associated metabolic reprogramming have profound effects on gene expression cellular differentiation and tumor microenvironment. Chemoresistant glioblastoma cells have upregulated key enzymes and regulators of fatty acid metabolism with enhanced exogenous uptake de novo synthesis and oxidation of fatty acids providing major energy support for cells during
therapeutic stress. Therefore targeting glioblastoma fatty acid metabolic pathways may be a new strategy to overcome chemoresistance
in glioblastoma.
|
|
Received: 06 March 2022
|
|
|
|
|
|
|
