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| The predictive value of controlled nutritional status score in postoperative recurrence and metastasis of breast cancer patients |
| 1 Ye Jian, 1 Zhang Jing, 2 Ji Liping, 3 Chen Lijuan |
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Department of Oncology, Rugao Hospital Affiliated to Nantong University,Rugao People's Hospital, Rugao 226500, Jiangsu, China;2
Department
of Nursing, Rugao Hospital Affiliated to Nantong University,Rugao People's Hospital, Rugao 226500, Jiangsu, China; 3
Department of Ra?
diotherapy, Rugao Hospital Affiliated to Nantong University, Rugao People's Hospital, Rugao 226500, Jiangsu, China |
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Abstract Objective To investigate the predictive value of controlled nutritional status (CONUT) for tumor recurrence and metastasis
of breast cancer patients. Method The clinicopathological features and survival follow⁃up data of 168 breast cancer patients who underwent
surgical resection in Rugao Peoples hospital from April 2013 to August 2019 were retrospectively collected. CONUT score was calculated
based on the lymphocyte count in the peripheral blood, preoperative serum albumin and total cholesterol levels. All patients were divided
into high CONUT (≥3 points) and low CONUT (<3 points) based on the preoperative CONUT score. Chi square test was used to evaluate
the relationship between CONUT score and clinicopathological features of breast cancer patients. Kaplan⁃Meier curves were plotted, and
the univariate and multivariate Cox regression analysis were conducted to investigate the prognostic value of CONUT score for breast
cancer patients. Result High CONUT (≥3 points) was significantly associated with advanced T stage (χ２= 6.666, P=0.036) and lymph
node metastasis(χ２ = 4.562, P=0.033). Kaplan⁃Meier curves showed that breast cancer patients with CONUT ≥3 had a higher risk of
recurrence and metastasis than those with CONUT <3, and the 5⁃year recurrence⁃free survival (RFS) of the two groups was 78.6% and
96.0%, respectively (χ２=11.562, P=0.001). Subgroup analysis further demonstrated that CONUT ≥3 was markedly correlated to poor RFS
of breast cancer patients, regardless of TNM Ⅰ-Ⅱ (5⁃year RFS: 82.6% vs 96.3%; χ２= 4.424, P=0.035) and stage Ⅲ (5⁃year RFS: 40.9%
vs 89.1%; χ２= 9.103, P=0.003). The results of univariate and multivariate analysis revealed that T stage (HR=3.875, 95%CI=1.080-13.903, P=0.038), lymph node metastasis (HR=3.354, 95%CI=1.166-9.645, P=0.025) and CONUT (HR=3.003, 95%CI=1.168-7.720, P=0.022)
were independent predictors of recurrence and metastasis in breast cancer patients. Conclusion CONUT could be used as an useful predictor
of recurrence and metastasis in breast cancer patients.
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Received: 15 September 2021
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