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| The relationship between human microecology and radiotherapy |
| Miao Mingyong |
| Department of Biochemistry, School of Basic Medicine, Naval Military Medical University, Shanghai 200433, China |
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Abstract The human microecology, especially the intestinal flora, is a new dynamic organ of the human body. The intestinal
flora and its metabolites can directly act on the intestine or indirectly through the microbiota⁃gut⁃organ axis to act on the whole body
tissues and organs and play an important role. The main physiological functions of human microecology include: regulating
gastrointestinal movement and digestion, intestinal barrier, regulating immune homeostasis and inflammatory response, material
metabolism, cell differentiation and turnover, and cognitive behavior. Radiotherapy can cause significant changes in the human
microbiota, manifested as changes in flora diversity and abundance. These changes are not only related to the efficacy of radiotherapy,
but also closely related to radiotherapy injury, complications and prognosis.At the same time, it was found that there were gender
differences in radiation efficacy and injury, which was related to the gender differences of intestinal flora. Therefore, maintaining and
adjusting the human microecological balance has an important impact on the efficacy of tumor radiotherapy and the prevention and
treatment of radiation damage and complications. The application of microecological preparations (probiotics, prebiotics and postbiotics)
and faecal microbiota transplantation play an obvious role in reducing tissue and organ damage caused by radiation, improving the
curative effect of radiotherapy and reducing complications. As an adjuvant anti⁃tumor therapy, it shows a good clinical application
prospect. Therefore, the optimal combination and application of disease⁃specific and individualized probiotics will be an important
research direction in the future.
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Received: 22 September 2021
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