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| Research progress on the effect of glucose and lipid metabolism disorders on malignant cancer |
| Pan Zhendong, Kong Weimin |
| Department of Gynecological Oncology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and
Child Health Care Hospital, Beijing 100006, China |
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Abstract Cancer is the leading cause of deaths worldwide and its incidence is increasing. Glucose/lipid metabolism disorders increase
the incidence and mortality of many malignant tumors, such as breast cancer, liver cancer, pancreatic cancer, colorectal cancer, etc. Multiple
mechanisms linking glucose/lipid metabolism and cancer progression have been described. The possible mechanisms include affecting the
cell metabolism, body inflammation and immune disorders, inhibiting tumor cell apoptosis, and promoting tumor cell proliferation and
metastasis. However, it remains unclear which factors are the main drivers of cancer development. The interaction between glucose/lipid
metabolism disorders and cancers restricts the choice of drugs, affects the efficacy of surgery and patient prognosis, making the formulation
of treatment plans more challenging. Metformin and statins may reduce the risk of a variety of cancers, but the results of relevant clinical
prospective trials are still unclear. Therefore, it is necessary to analyze the research progress related to glucose/lipid metabolism disorders
and cancers. This review aims to explore the association between glucose/lipid metabolism disorders and the occurrence of cancers. Discuss
the evidence supporting glucose/lipid metabolism disorders in cancers and how this phenotype may contribute to cancers growth and
progression. Finally, the potential role of blood glucose or lipid lowering strategies for the treatment of cancers will be discussed.
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Received: 11 July 2021
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