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| Research progress on tumor metabolic reprogramming and its relationship with gut microbiota |
| Liu Fubin, Song Fangfang |
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Abstract Metabolic phenotypes are often altered during the process of tumor onset and development. This metabolic
reprogramming mode not only comprises traditional nutrient sources (glucose, lipids, glutamine), but also lactate, acetate, ketone
bodies and exogenous proteins can also be re⁃ingested and utilized by cancer cells. A healthy gut microbiota maintains
homeostasis and normal intestinal function, and has important physiological significance in regulating host energy metabolism,
promoting food digestion, and modulating immunity. However, the metabolites of the gut microbiota are capable of reshaping the
nutritional microenvironment of tumors, forcing cancer cells to support their own proliferation and metastasis by changing their
metabolic manners. In this paper, we systematically reviewed the nutrient sources involved in tumor metabolic reprogramming
and its regulation by gut microbiota. On the one hand, tumor metabolism is reprogrammed, and tumor cells continuously absorb
various nutrients from the surrounding environment to provide energy for their own growth and proliferation. On the other hand,
the gut microbiota modulates the process of tumor metabolic reprogramming through its metabolites. At the same time, tumor
metabolites possess a feed⁃back effect on the gut microbiota and then the intestinal ecological balance. It is particularly crucial to
understand the mechanism of tumor metabolic reprogramming and reveal the interaction between the gut microbiota and tumor
metabolism. This will provide a good theoretical basis for the exploration of effective metabolic targeted prevention and treatment
strategy and potential drugs for cancer in the future.
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Received: 15 June 2020
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