omega-3脂肪酸用于肿瘤恶液质患者口服营养补充的meta分析

doi:10.16689/j.cnki.cn11-9349/r.2020.04.014

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Abstract Objective To systematically evaluate the clinical efficacy of oral nutritional supplements of omega-3 fatty acids in patients with cancer cachexia. Methods PubMed, EMbase, SinoMed, Web of Science, CNKI and Wanfang Data databases were comprehensively searched to collect randomized controlled trial on oral nutritional supplements containing omega 3 Fatty Acids for cancer cachexia from January 1, 2000 until July 4, 2020. Two reviewers independently screened literature based on inclusion and exclusion criteria, and then evaluated the risk of bias and literature quality of the included studies in accordance with the Cochrane Handbook of Systematic Reviews of Interventions and the modified Jadad scoring scale. Finally, meta-analysis was performed using Revman 5.3 software. Results A total of 316 potential related articles were searched and 54 articles were obtained after preliminary screening. Finally, we determined a total of 7 randomized controlled trials (RCTs) involving 901 patients. The result of meta-analysis showed that: compared with placebo group, oral nutritional supplements containing omega 3 Fatty Acids significantly put on weight (MD=2.4kg, 95%CI=2.26-2.53, P<0.001) and improve the quality of life(MD=4.71, 95%CI=3.99-5.42, P<0.001). However, lean body mass showed no statistically significant difference between the two groups(MD=﹣0.79, 95%CI=-2.09-0.51), P=0.23)；Qualitative analysis of survival time showed that ONS containing omega-3 fatty acids could not delay the course of cachexia and prolong the survival time of patients. Conclusion Oral nutritional supplements containing omega-3 fatty acids have the potential to improve the quality of life in patients with cancer cachexia.

Key words： Cancer Cachexia Omega 3 fatty acids Meta-analysis Randomized controlled trial

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	Articles by authors
	Li Ting
	Zeng Jun
	Deng Hongfei
	Wang Yu
	Jiang Hua

Cite this article:

Li Ting,Zeng Jun,Deng Hongfei, et al. Meta-analysis of the use of oral nutritional supplements containing omega-3 fatty acids for patients with cancer cachexia[J]. Electron J Metab Nutr Cancer, 2020, 7(4): 448-454.

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http://182.92.200.144/EN/10.16689/j.cnki.cn11-9349/r.2020.04.014 OR http://182.92.200.144/EN/Y2020/V7/I4/448

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