VEGF、TGF-β1和PD-L1在上皮性卵巢癌组织中的表达及其临床意义

doi:10.16689/j.cnki.cn11-9349/r.2020.03.019

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Abstract Objective To investigate the expressions of VEGF, TGF-β1 and PD-L1 proteins in epithelial ovarian cancer, and to explore the association of the expressions of VEGF, TGF-β1 and PD-L1 with clinicopathological features. Methods Immunohistochemistry was used to detect the expressions of VEGF, TGF-β1 and PD-L1 in 46 cases of epithelial ovarian cancer, 20 cases of benign ovarian cystadenoma and 20 cases of normal ovarian, and analyzing the association of the expressions of VEGF, TGF-β1 and PD-L1 with the clinicopathological features. Results Immunohistochemistry showed that the positive expression rates of VEGF in epithelial ovarian cancer, benign ovarian cystadenoma tissue and normal ovarian tissue were 65.2% (30/46), 25.0% (5/20) and 15.0% (3/20), respectively. The positive expression rates of TGF-β1 in epithelial ovarian cancer, benign ovarian cystadenoma tissue and normal ovarian tissue were 82.6% (38/46), 30.0% (6/20) and 20.0% (4/20), respectively. The positive expression rates of PD-L1 in epithelial ovarian cancer tissues, benign ovarian cystadenoma tissue and normal ovarian tissue were 89.1% (41/46), 30.0% (6/20) and 25.0% (5/20), respectively. The positive rates of VEGF, TGF-β1 and PD-L1 in epithelial ovarian cancer tissues were higher than those in benign and normal ovarian tissues, with statistically significant differences (P<0.01). The expression of VEGF, TGF-β1 and PD-L1 in epithelial ovarian cancer was associated with FIGO staging and lymph node metastasis (P<0.05), and TGF-β1 was also associated with CA125 (P<0.05). In epithelial ovarian cancer,VEGF level was positively correlated with TGF-β1 (r=0.387, P<0.05)；VEGF level was positively correlated with PD-L1 (r=0.332, P<0.05)；TGF-β1 was positively correlated with PD-L1 (r=0.393, P<0.05). Conclusions The expressions of VEGF, TGF-β1 and PD-L1 were significantly up-regulated in epithelial ovarian cancer tissues and the above factors showing a positive correlation. The correlation with FIGO staging and lymph node metastasis suggested that VEGF, TGF-β1 and PD-L1may interact with each other through some mechanism to promote the progress of epithelial ovarian cancer, and the combined detection may guide the early diagnosis and treatment of epithelial ovarian cancer.

Key words： Ovarian neoplasms｜Gene｜Vascular endothelial growth factor｜Transforming growth factor-β1｜Programmed cell death ligand 1

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	Hou Jianying
	Zhu Wei

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Hou Jianying,Zhu Wei. Expressions of VEGF, TGF-β1 and PD-L1 in epithelial ovarian cancer and its clinical significance[J]. Electron J Metab Nutr Cancer, 2020, 7(3): 352-358.

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http://182.92.200.144/EN/10.16689/j.cnki.cn11-9349/r.2020.03.019 OR http://182.92.200.144/EN/Y2020/V7/I3/352

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