PLR、NLR对食管鳞癌放化疗/放疗患者预后的影响

doi:10.16689/j.cnki.cn11-9349/r.2020.03.015

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Abstract Objective To investigate the effect between platelet to lymphocyte ratio (PLR), neutrophil to lymphocyte ratio (NLR) and the prognosis of patients with esophageal squamous cell carcinom(ESCC) a undergoing chemoradiotherapy or radiotherapy. Methods Retrospective analysis was performed for 143 cases with histologically confirmed ESCC that underwent chemoradiotherapy or radiotherapy from March 2012 to November 2017. The cutoff values of NLR and PLR were determined by ROC curve, and the patients were divided into high value group and low value group respectively. The chi-square test was used to compare the differences between different groups；Kaplan-Meier method was used to calculate the overall survival (OS)；log-rank test method was used for univariate analysis and Cox regression model for multivariate analysis. Results ROC curve analysis showed that PLR ＝189, NLR=3.55 were optimal cut-off values, 120 cases in low PLR group (<196.67), 23 cases in high PLR group (≥ 196.67)；96 cases in low NLR group (<3.55), 47 cases in high NLR group (≥ 3.55).The level of PLR and NLR before chemoradiotherapy or radiotherapy was not related to sex, age, tumor length, T stage, N stage and other clinicopathological features(P>0.05).Univariate analysis showed that T stage, N stage, treatment method, PLR and NLR are correlated with the overall survival of patients with esophageal squamous cell carcinoma before chemoradiotherapy or radiotherapy(P<0.05). Multivariate analysis revealed that the PLR, treatment method and T stage were identified as independent prognostic factors for the overall survival of ESCC patients(P<0.05), PLR is better than NLR in predicting the prognosis of esophageal cancer patients. Conclusion PLR and NLR might predict the prognosis of ESCC patients. PLR could be an independent prognostic factor for ESCC.

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	Articles by authors
	Li Ke
	Li Tao
	Lyu Jiahua
	Xiao Ling
	Liu Xiao

Cite this article:

Li Ke,Li Tao,Lyu Jiahua, et al. Correlation between PLR, NLR and the prognosis of patients with esophageal squamous cell carcinoma undergoing chemoradiotherapy or radiotherapy[J]. Electron J Metab Nutr Cancer, 2020, 7(3): 327-332.

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http://182.92.200.144/EN/10.16689/j.cnki.cn11-9349/r.2020.03.015 OR http://182.92.200.144/EN/Y2020/V7/I3/327

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