握力和炎症因子与胃癌患者主观整体评估的相关分析

doi:10.16689/j.cnki.cn11－9349/r.2019.04.013

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Abstract ObjectiveTo assess the nutritional status and analyze the correlation among objective indicators of anthropometric, blood biochemistry and inflammatory factors. Methods 150 patients with simple gastric cancer hospitalized in the first department of abdomen surgy of Jianxi tumor hospital from June 2017 to February 2018 were consecutively enrolled in this study. The nutritional status was assessed by patient-generated subjective global assessment （PG-SGA）in their first 24 hours in hospital. The blood routine, blood biochemistry and inflammatory factors were detected. The height, weight, BMI, dominant handgrip strength and Karnofsky performance status （KPS） were measured. Pearson correlation and multivariate stepwise logistic regression analyses were used to analyze the related factors of nutritional status. ResultsFor the 150 patients with gastric cancer, there were 29 patients （19.33%） with well-nourished （0~1 point）, 39 patients （26.00%） with suspected or mild malnutrition （2~3 points）, 60 patients （40.00%） with moderate malnutrition （4~8 points） and 22 patients （14.67%） with severe malnutrition （≥9 points）. The height, weight, BMI, Hb, ALB, TG and dominant handgrip strength of patients in the malnutrition group （≥2 points） were significantly lower than those in the well-nourished group （0~1 point）, while the age, interleukin 2 （IL-2） and TNF-α levels were significantly higher than those in the well-nourished group （P<0.05）. Pearsons correlation analyses showed that PG-SGA score was positively correlated with age （r=0.242）, IL-2 （r=0.284）,TNF-α （r=0.230） and negative correlated with BMI （r=-0.310）, KPS （r=-0.463）, Hb （r=-0.233）, ALB （r=-0.267） and dominant handgrip strength （r=-0.490）（P<0.05）. Logistic stepwise regression analysis showed that age （OR=1.122）, IL-2 （OR=1.010）, TNF-α level （OR=1.139） and dominant handgrip strength （OR=0.832） were independent risk factors for malnutrition in gastric cancer patients before surgery. ConclusionThe incidence of preoperative malnutrition in patients with simple gastric cancer is relatively high, and their nutritional status can be monitored and evaluated by PG-SGA combined with objective indicators such as anthropometric measurements and inflammatory factors.

Key words： Gastric cancer Patient-generated subjective global assessment Nutritional status Malnutrition Inflammatory factors

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	Articles by authors
	1PENG Xiao-hui
	2XIONG Ling
	1WU Qi
	1YUAN Hui-hua
	1SUN Li

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1PENG Xiao-hui,2XIONG Ling,1WU Qi, et al. The correlation between handgrip strength, inflammatory factors and patient-generated subjective global assessment score in preoperative patients with gastric cancer[J]. Electron J Metab Nutr Cancer, 2019, 6(4): 457-461.

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http://182.92.200.144/EN/10.16689/j.cnki.cn11－9349/r.2019.04.013 OR http://182.92.200.144/EN/Y2019/V6/I4/457

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