肿瘤微环境下的代谢重编程调控

doi:10.16689/j.cnki.cn11－9349/r.2019.04.003

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Abstract The occurrence, growth and metastasis of tumors are associated with its microenvironment. Cancer cells are surrounded by different kinds of cells, such as cancer-associated fibroblasts, immune cells. These cells establish a defensive microenvironment against tumors under the condition of hypoxia or nutrient deprivation. Under this complicated microenvironment, cancer cells reprogram their metabolic signatures to resist the killing function of immune cells. In this paper, we describe the regulation of metabolic reprogramming of cancer cells in two perspectives. On the one hand, in addition to traditional nutrients, tumor cells can acquire and utilize other nutrients in a special way to support rapid and unrestricted proliferation, such as lactic acid, ketone bodies, acetic acid, and branched-chain amino acids. These substances also play a vital role in the development of tumors. On the other hand, cancer cells can affect and regulate the surrounding immune cells and fibroblasts through metabolic changes under the lack of oxygen and nutrition. Cancer-associated fibroblasts can provide a variety of nutrients or growth factors to regulate the metabolism, meanwhile multiple metabolites from cancer cells inhibit the normal functions and the anti-tumor effects of surrounding immune cells. Ultimately, the microenvironment is transformed to be favorable for proliferation and development of tumors.

Key words： Cancer Metabolic reprogramming Microenvironment Cancer-associated fibroblasts Immune cells

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	YE Ling
	ZHANG Hua-feng
	LI Shi-ting

Cite this article:

YE Ling,ZHANG Hua-feng,LI Shi-ting. Regulation of metabolic reprogramming in the tumor microenvironment[J]. Electron J Metab Nutr Cancer, 2019, 6(4): 401-408.

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http://182.92.200.144/EN/10.16689/j.cnki.cn11－9349/r.2019.04.003 OR http://182.92.200.144/EN/Y2019/V6/I4/401

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