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Abstract Objective To investigate the effect of oral nutrition supplementation on the nutritional status of esophageal cancer patients under radiotherapy.Methods A total of 100 patients with esophageal cancer admitted to the oncology department of The 989 Hospital of Joint Logistic Support Force of People’s Liberation Army from September 2016 to April 2018 who were able to eat through mouth and were prepared to undergo linear accelerator conformal intensity modulated radiotherapy (60Gy/30F) with PG-SGA score ≥4 were selected as research object. Random number table method was used to divide the study group (ONS group) and the control group (routine liquid group).The changes of energy， protein intake， body weight and albumin， hemoglobin， lymphocyte count and other related nutritional indicators before and after radiotherapy were compared between the two groups. Results Before radiotherapy， there were no statistically significant differences in age， weight， BMI， KPS score， PG-SGA score and nutrition-related indexes between the two groups (P>0.05). After radiotherapy， both groups lost weight， but the weight loss in the study group was no statistical significance (P>0.05). The levels of hemoglobin， lymphocyte， albumin and leukocyte in the control group all decreased significantly after radiotherapy (P<0.05). There was a significant decrease in lymphocytes in the study group after radiotherapy (P<0.05)， but no significant decrease in albumin， hemoglobin and leukocyte levels (P>0.05). Conclusion For patients with esophageal cancer who can eat through mouth but cannot meet nutritional requirements， ONS is beneficial to maintain energy and protein， maintaining body weight after radiotherapy， and improving nutritional status.
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