1Nutrition Department， Ningxia Medical University General Hospital， Yinchuan 750004， Ningxia， China; 2Neurosurgery Department， Ningxia Medical University General Hospital， Yinchuan 750004， Ningxia， China
Abstract Objective To investigate the effect of perioperative nutritional therapy in patients with meningioma. Methods 65 patients who underwent meningioma resection from January 2017 to November 2018 were selected and randomly divided into two groups: observation group (n=32) and control group (n=33). To observe and compare the differences of postoperative fasting blood glucose， serum albumin， inflammatory index， hospital stay and hospitalization cost between the two groups. Results The results of repeated analysis of variance showed statistically significant differences in albumin and white blood cell count (P<0.05)， with an F value of 8.450 and 18.647. Pairwise comparison results showed that the two groups of fasting blood glucose， serum albumin， white blood cell count， along with the change of time were different. Fasting blood glucose on the third day and white blood cell count on the 3/5/8 day after operation were lower than those of the control group. The albumin level on the first day after the operation was higher than that of the control group (P<0.05). Compared to the control group and the observation group， postoperative hospitalization days (13.63±3.82) d vs (16.58± 6.60) d， and antibiotic cost (2，923± 562.83) yuan vs(431.37± 104.74) yuan， have statistically significant (P<0.05). Conclusion Perioperative nutritional therapy plays a certain role in maintaining negative nitrogen balance in patients with meningioma， preventing inflammatory reaction and shortening hospital stay.
1XUE Tao,1WANG Wei-hong,2MA Hui, et al. Application of perioperative nutritional support in patients with meningioma[J]. Electron J Metab Nutr Cancer, 2019, 6(3): 326-331.
1.王忠诚. 王忠诚神经外科学［M］. 湖北科学技术出版社，2004:587.
2.ChampeauxC，Weller J，Katsahian S. Epidemiology of meningiomas. A nationwide study of surgically treated tumours on French medico-administrative data.Cancer Epidemiology.2019;58:63-70.
3.Ostrom QT， Gittleman H， Fulop J， et al. CBTRUS statistical report: primary brain and central nervous system tumors diagnosed in the United States in 2008-2012(Article). Neuro Oncol. 2015;17 Suppl 4:iv1-iv62.
4.Elwyn DH， Bryan B， Christopher W， et al. Nutritional aspects of body water dislocations in postoperative and depleted patients. Ann Surg.1975;182(1):76-85.
5.Kinney JM，Weissman C.Forms of malnutrition in stressed and unstressed patients. Clin Chest Med.1986;7(1):19-28.
6.Santos JI. Nutrition， infection， and immunocompetence. Infect Dis Clin North Am.1994;8(1):243-267.
7.Bona S，Molteni M，Rosati R，et al.Introducing an enhanced recovery after surgery program in colorectal surgery: a single center experience.World J Gastroentero.2014;20(46):17578-17587.
8.Currie A， Soop M， Demartines N，et al.Enhanced recovery after surgery interactive audit system: 10 years’ experience with an international web-based clinical and research perioperative care database. Clin Colon Rectal Surg.2019;32(1):75-81.
9.Ferrie S，Allman FM，Daley M，et al.Protein requirements in the critically ill: a randomized controlled trial using parenteral nutrition. JPEN J Parenter Enteral Nutr.2016;40(6):795-805.
10.Nygren J，Thorell A， Jacobsson H，et al.Preoperative gastric emptying effects of anxiety and oral carbohydrate administration. Ann Surg. 1995;222(6):728-734.
11.Doo AR， Hwang H，Ki MJ，et al.Effects of preoperative oral carbohydrate administration on patient well-being and satisfaction in thyroid surgery. Korean J Anesthesiol.2018 ;71(5):394-400.
12.Lee SH，Jang JY，Lee JG.Nutrition support in trauma patients.Clin Nutr Insight. 2013;20(9):137-144.
13.Salter KL， McClure JA， Foley NC， et al.Pharmacotherapy for depression posttraumatic brain injury: a meta-analysis. J Head Trauma Rehabil. 2016;31(4):21-32.
14.Esahili AH， Boija PO， Ljungqvist O，et al.Twenty-four hour fasting increases endotoxin lethality in the rat. Eur J Surg.1991;157(2):89-95.
15.Stephen ARK，Robert GM，Daren KH，et al.Summary points and consensus recommendations from the north American surgical nutrition summit. JPEN J Parenter Enteral Nutr.2013;37(1):99s-105s.
16.Liu B，Wang Y，Liu S，et al.A randomized controlled study of preoperative oral carbohydrate loading versus fasting in patients undergoing elective craniotomy. Clin Nutr. 2019;38(5):2106-2112. doi: 10.1016/j.clnu.2018.11.008. Epub 2018 Nov 17.
17.Bochicchio GV，Joshi M，Bochicchio KM，et al.Early hyperglycemic control is important in critically injured trauma patients. J Trauma. 2007;63(6):1353-1358.
18.Fujikuni N，Tanabe K，Tokumoto N，et al.Enhanced recovery program is safe and improves postoperative insulin resistance in gastrectomy. World J Gastrointest Surg.2016;8(5):382-388.
19.Burch J. Preoperative carbohydrate loading in the enhanced recovery pathway. Br J Nurs.2016;25(12):669-672.
20.薛志刚，于健春，康维明，等.围术期营养干预加速胃肠外科术后康复:单中心前瞻队列研究.协和医学杂志.2018;9(6):526-532.
21.栗超跃，赵黎明，娄岳，等.快速康复外科对神经外科手术疗效的影响.中国神经精神疾病杂志.2014;40(10):620-623.
22.Martin L， Gillis C， Atkins M， et al. Implementation of an enhanced recovery after surgery program can change nutrition care practice: a multicenter experience in elective colorectal surgery. JPEN J Parenter Enteral Nutr.2019;43(2):206-219.
23.Koretz RL， Avenell A， Lipman TO， et al.Does enteral nutrition affect clinical outcome? A systematic review of the randomized trials. Am J Gastroenterol.2007;102(2):412-429.
24.McClave SA， Heyland DK. The physiologic response and associated clinical benefits from provision of early enteral nutrition. Nutr Clin Pract.2009;24(3):305-315.
