中性粒细胞与肿瘤复杂相关性的研究进展

doi:10.16689/j.cnki.cn11－9349/r.2019.02.003

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Abstract Neutrophils have multiple functions， including the ability to secrete chemokines and cytokines， the ability to form extracellular traps， antigen presentation， and the ability to regulate tumor proliferation and metastasis. The findings of neutrophil plasticity and heterogeneity suggest that circulating neutrophils and tumor-associated neutrophils play a significant role in the regulation of tumor proliferation and metastasis. On the one hand， neutrophils promote tumor inflammation， tumor cell proliferation and invasion， and tumor angiogenesis. Besides， it can promote tumor immune escape by inhibiting the activity of cytotoxic T cells. On the other hand， neutrophils can promote the antitumor effect of T cells and participate in tumor inhibition by producing corresponding cytokines. Previously， the study of tumor-associated neutrophils was based on animal models. Recently， some studies have further pointed out the understanding of human tumor-associated neutrophil， and explored the possibility of neutrophils becoming a new target of tumor immunotherapy. At present， many studies on the complex relationship between tumors and neutrophils have shown that cell therapy plays an important role in the understanding of tumor biology， the development of tumor markers and the treatment of tumor. This article reviews the progress in the study of the relationship between neutrophils and tumor complexity.

Key words： Circulating neutrophils Tumor-associated neutrophils Tumor targeting therapy

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	GUO Fei-fei
	CUI Jiu-wei

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GUO Fei-fei,CUI Jiu-wei. Progress in the study of the complex correlation between neutrophil and tumor[J]. Electron J Metab Nutr Cancer, 2019, 6(2): 167-171.

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http://182.92.200.144/EN/10.16689/j.cnki.cn11－9349/r.2019.02.003 OR http://182.92.200.144/EN/Y2019/V6/I2/167

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