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Electron J Metab Nutr Cancer  2019, Vol. 6 Issue (1): 75-78    DOI: 10.16689/j.cnki.cn11-9349/r.2019.01.014
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Expression and clinical significance of miR-10a and let-7i in endometrial carcinoma
1Department of Gynaecology and Obstetrics, The First Central hospital of  Baoding, Baoding 071000, Hebei, China; 2Department of Gynaecology and Obstetrics, The First Hospital of Hebei Medical University, Shijiazhuang 050011, Hebei, China.
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Abstract   Objective  To investigate the expression of miR-10a and let-7i in endometrial carcinoma tissues and its significance. Methods  Forty cases of endometrial carcinoma,twenty cases of atypical hyperplasia and thirty cases of normal endometrium tissues were collected, poly (A)-RT-qPCR was employed to test the expression of miR-10a and let-7i in different endometrial tissues. The statistical analyses were performed between the expression of miR-10a and let-7i and the clinicopathological characteristics. Results  The expression of miR-10a was higher in endometrial carcinoma tissues than that of normal endometrium and atypical hyperplasia tissues (P<0.01). The expression of miR-10a in patients with grade 3 of pathology was higher than that 1+2, in stage Ⅲ+Ⅳof endometrial carcinoma patients was higher than stageⅠ+Ⅱ, in patients with lymph node metastasis was higher than that without lymph node metastasis , in patients that myometrial invasion≥1/2 was higher than that<1/2. The expression of miR10a in different age, whether ER-positive, PR-positive had no statistical difference (P>0.05).  The expression of let-7i was lower in endometrial carcinoma tissues than that of normal endometrium and atypical hyperplasia tissues (P<0.01)。Conclusions  In endometrial carcinoma tissues, the expression of miR-10a was up-regulated, let-7i was down-regulated, miR-10a may promote invasion and metastasis of endometrial carcinoma.
Key words Endometrial carcinoma      MiR-10a      Let-7i
     
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Articles by authors
1QI Li-ning
2ZHANG Hong-zhen
2WEI Xu-jing
1GUO Yan-pu
1ZHAI Ai-li
1WANG Qi
1LI Miao
Cite this article:   
1QI Li-ning,2ZHANG Hong-zhen,2WEI Xu-jing, et al. Expression and clinical significance of miR-10a and let-7i in endometrial carcinoma[J]. Electron J Metab Nutr Cancer, 2019, 6(1): 75-78.
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http://182.92.200.144/EN/10.16689/j.cnki.cn11-9349/r.2019.01.014     OR     http://182.92.200.144/EN/Y2019/V6/I1/75
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