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| Mitochondrial DNA mutation in cervical cancer |
| 1 FENG Da-li, 2 ZHOU Fu-xiang |
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Abstract Mitochondria are the organelles of the eukaryotic cells that oxidize phosphorylation to produce ATP and are closely related to cell energy metabolism, cell apoptosis, oxidative stress, calcium homeostasis control and so on. Mitochondria have mitochondrial DNA(mtDNA), a genetic material independent of nuclear genes. mtDNA is the only genetic material outside nuclear,because of its unique structural characteristics and biological environment, which is prone to mutation with about 10 times the rate to nuclear genome. A large number of research show that mtDNA is highly related to the occurrence and development of human tumor. Cervical cancer(CC) is the most common gynecologic malignant tumor that endangers human health. Its incidence is the second of female malignant tumor in the world, second only to breast cancer.With the development of the economy and society, the spectrum of human disease has changed greatly. But the incidence and mortality of CC remain high. There are many studies on the correlation between the genome nucleus and cervical carcinoma, but the research on genome outside the nuclear are rare.In recent years, study
on relationship between mtDNA and CC has become a hot research topic. Mutations in mtDNA include qualitative mutations, such as base substitution, insertion or deletion, and changes in the content of mtDNA, etc. Many previous studies include the effect of mtDNA mutation on different aspect of CC. This paper reviews the relevance between the mutation of mtDNA and occurrence,development, prognosis of CC.
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| [1] |
WANG Chao-yun， DU Cheng， GUAN Xin， DU Xiao-wei， XU Zhu-xuan， ZHENG Zhen-dong. Advances in drug therapy for cancer cachexia[J]. Electronic Journal of Metabolism and Nutrition of, 2019, 6(3): 382-385. |
| [2] |
SHENG Xiang， LI Su-yi. Advances in research on intestinal microecology and clinical outcomes of tumors[J]. Electronic Journal of Metabolism and Nutrition of, 2019, 6(2): 178-182. |
| [3] |
1, 3YUAN Fei, 2, 3, 4WANG Shu-bin. Progress of ribosomal protein in malignant tumor therapy[J]. Electronic Journal of Metabolism and Nutrition of, 2019, 6(1): 116-119. |
| [4] |
1FENG Da-li; 2ZHU Wen-liang; 3YIN Yi-fa. Research progress on relationship between mtDNA and tumor[J]. Electronic Journal of Metabolism and Nutrition of, 2019, 6(1): 150-154. |
| [5] |
XIE Lin-ying, WANG Chang, WU Hai-tao, WANG Yi-zhuo, LIANG Ting-ting, HE Hua, YAO Cheng, LI Wei. The analysis and the investigation of malnutrition in 744 elderly inpatients with tumor[J]. Electronic Journal of Metabolism and Nutrition of, 2018, 5(4): 380-386. |
| [6] |
1LI Tao, 1LV Jia-hua,1LANG Jin-yi, 2SHI Han-ping, 3XU Hong-xia, 4LI Bao-sheng, 5ZHANG Zhen, 6 ZHU Shu-chai, 7CHEN Ming, 8KANG Jing-bo, . Expert consensus on nutrition therapy in cancer patients receiving radiotherapy[J]. Electronic Journal of Metabolism and Nutrition of, 2018, 5(4): 358-36. |
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