|
|
|
| Ribosomal protein family in tumorigenesis and development |
| 1, 2YUAN Fei, 2, 3, 4WANG Shu-bin, 2, 3, 4WANG Yue-li |
| 1Department of Laboratory, Baotou Central Hospital, Baotou 014040, Inner Mongolia Autonomous Region, China; 2Cancer Prevention and Treatment Research Institute of Baotou Medical College, Baotou 014040, Inner Mongolia Autonomous Region, China; 3Department of Oncology, Baotou Institute of Medical Sciences, Baotou 014040, Inner Mongolia Autonomous Region, China; 4Department of Oncology, Baotou Central Hospital, Baotou 014040, Inner Mongolia Autonomous Region, China |
|
|
|
|
Abstract Ribosomal protein (RP) is a major component of the ribosome which are the sites of protein synthesis. However, RP is not stale, easy to be degradated by nuclear protease. When the synthesis of cellular ribosomal subunits is increased, the abnormal regulation of cell function and metabolic disorder leads to abnormal cell proliferation and dysfunction, and even malignant transformation. Tumor onset and progression, often accompanied by genomic instability, will lead to the change of encoding ribosomal protein gene, tumor regional hypoxia and nutritional deficiencies. Chemical drugs used in treatment and radiation may affect the ribosome synthesis, ribosomal protein imbalance or dysfunction. All of these factors lead to ribosomal stress, which stimulates the formation of ribosomal proteins in the form of free ribosomes. The rapid growth and proliferation of tumor cells requires more ribosome synthesis mechanism than somatic cells, which promotes the synthesis of ribosomes. A large number of studies have confirmed the abnormal expression of ribosomal proteins in tumors, suggesting that ribosomal proteins play an important role in the development and progression of human diseases and tumors. Ribosomal protein family, the key members of the body for protein synthesis, play an irreplaceable role in the process of genetic information transfer and also play other functions besides protein translation. The research results showed the ribosomal protein family could regulate tumor cell cycle and apoptosis, and promote tumor proliferation, infiltration, metastasisangiogenesis, or ohter malignant biological behaviors through regulating oncogenes and tumor suppressor gene expression or collaborating with chromosome genes. The ribosomal protein family which play an important role in the occurrence and development of the tumor, is one of the important factors in promoting tumor occurrence and development.
|
|
|
|
|
|
| [1] |
WANG Chao-yun， DU Cheng， GUAN Xin， DU Xiao-wei， XU Zhu-xuan， ZHENG Zhen-dong. Advances in drug therapy for cancer cachexia[J]. Electronic Journal of Metabolism and Nutrition of, 2019, 6(3): 382-385. |
| [2] |
SHENG Xiang， LI Su-yi. Advances in research on intestinal microecology and clinical outcomes of tumors[J]. Electronic Journal of Metabolism and Nutrition of, 2019, 6(2): 178-182. |
| [3] |
1, 3YUAN Fei, 2, 3, 4WANG Shu-bin. Progress of ribosomal protein in malignant tumor therapy[J]. Electronic Journal of Metabolism and Nutrition of, 2019, 6(1): 116-119. |
| [4] |
XIE Lin-ying, WANG Chang, WU Hai-tao, WANG Yi-zhuo, LIANG Ting-ting, HE Hua, YAO Cheng, LI Wei. The analysis and the investigation of malnutrition in 744 elderly inpatients with tumor[J]. Electronic Journal of Metabolism and Nutrition of, 2018, 5(4): 380-386. |
| [5] |
1LI Tao, 1LV Jia-hua,1LANG Jin-yi, 2SHI Han-ping, 3XU Hong-xia, 4LI Bao-sheng, 5ZHANG Zhen, 6 ZHU Shu-chai, 7CHEN Ming, 8KANG Jing-bo, . Expert consensus on nutrition therapy in cancer patients receiving radiotherapy[J]. Electronic Journal of Metabolism and Nutrition of, 2018, 5(4): 358-36. |
| [6] |
ZHANG Xiao-wei, CHENG Xue-jiao, LI Yao, WANG Kai, DONG Guan-nan. Observation on the effect of complex protein components on the nutritional status of patients with malignant tumors in digestive tract[J]. Electronic Journal of Metabolism and Nutrition of, 2018, 5(4): 372-375. |
|
|
|
|
