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| Omega-3 PUFAs reduces postoperative infection in digestive system malignant tumor patients: a Meta-analysis |
| HAN Fu-jun, LI Yan, LI Wei, TIAN Hui-min, CUI Jiu-wei |
| The First Hospital of Jilin University, Changchun 130021, China |
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Abstract Objective To systematically review the effect of omega-3 PUFAs supplementation on postoperative patients with gastrointestinal cancer. Methods Databases of MEDLINE, EMBASE, cochrance central register of controlled trials, CNKI and CBM had been searched. The start time of retrieval is the default database, the deadline of retrieval is August 2016. The search terms were omega-3 PUFAs, omega-3 fatty acids, fish oil, gastrointestinal cancer, digestive system neoplasms, postoperative infection. According to include and exclude standard screening high quality randomized controlled trials, two groups independently reviewed articles, extracted data and assessed the methodological quality. RevMan 5.2 was used for statistical analysis. Results 928 articles were retrieved, 6 high-quality randomized controlled trials with 404 patients, from 4 different countries and nationalities were included. Meta-analysis results showed that the incidence of infection in the ω-3PUFAs group was lower than that in the control group, and the difference was statistically significant (OR=2.2, 95%CI=1.05~4.61, P=0.037). Subgroup analysis on country, time of omega-3 PUFAs supplements intake and ways of nutritional support, for the limitation of the number of the patients, subgroup analysis was unable to draw any definitive results. Conclusions Supplement with omega-3 PUFAs may reduce the incidence of infection complications on postoperative patients with gastrointestinal cancer. However, there was a high heterogeneity (I2=54.7%, P=0.051). Because of limitation of the number of patients included in the study, subgroup analysis was unable to draw any definitive conclusions, large prospective clinical trials are needed for this topic.
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