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| Immune enteral nutrition on elderly advanced lung cancer patients with chemoherapy |
| LIU Su-yao, WANG Jun, FAN Wei-fei, MAO Yuan, Wang Lin, XU Ju-qing |
| Department of Oncology, Jiangsu Province Geriatric Hospital, Nanjing 221000, China |
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Abstract Objective To Investigate the effect of immune nutrition on elderly advanced NSCLC patients with chemoherapy. Methods 91 cases of elderly advanced NSCLC patients were selected from our hospital. They were divided into three groups, the first group was immune-enhanced enteral nutrition intervention group (29 patients with normal diets supplemented with immune enhanced enteral nutrition 1,000ml/d), the second group was conventional enteral nutrition intervention group (32 patients supplemented with conventional enteral nutrition 1,000ml/d), the third group was control group (30 patients supplemented with normal diet). We recorded indicators of patients 1 day before chemotherapy and 1 month, 2 months, 3 months after treatment separately including weight, BMI, AC, ALB, HB and PG-SGA score. Then, we compared the differences of adverse reactions among these three groups, such as pulmonary infection, fatigue, nausea, vomiting, diarrhea and constipation. Results All the 91 cases patients completed at least 3 cycles of chemotherapy. Nutritional indicators such as AC, ALB, HB were decreased after chemotherapy in all patients, but PG-SGA scores raised, with significant difference. In group III, nutritional indicators deteriorated significantly higher than other two groups. However, in group I, the decrease of AC, HB and the increase of PG-SGA were less than group II, with statistical differences. Conclusions Chemotherapy could make elderly advanced NSCLC patients worsening in nutritional status. Compared with conventional dietary, supplemented enteral nutrition could serve to maintain body weight and slow down the deterioration of the nutritional status. In addition, compared with standard enteral nutrition, immune enhanced enteral nutrition can better improve AC and PG-SGA score, while reducing the probability of pulmonary infections during chemotherapy, therefore, we believed that the immune-enhancing enteral nutrition is better.
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