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| The predictive value of the pre - treatment hemoglobin albumin lymphocyte and platelet score for the prognosis of
radiotherapy in esophageal squamous cell carcinoma |
| 1Zhang Xue,1 Xiao Ling,2 Zheng Xiumei,1Liu Yuxin,3Mu Chunxiao,4 Ni Shuang,2Lyu Jiahua |
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School of Medicine University of Electronic Science and Technology of China Chengdu 610041 Sichuan China
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Second Department of
Thoracic Radiotherapy Sichuan Cancer Hospital Chengdu 610041 Sichuan China
3 Department of Clinical Medicine Southwest Medical
University Luzhou 646000 Sichuan China
4Department of Clinical Medicine Chengdu Medical College Chengdu 610041 Sichuan China |
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Abstract Objective To investigate the predictive value of the pre-treatment hemoglobin-albumin-lymphocyte-platelet HALP
score for overall survival in patients with esophageal squamous cell carcinoma ESCC undergoing radical radiotherapy and to construct
a nomogram model to evaluate its predictive performance. Method A retrospective analysis was conducted on 246 patients with stage
Ⅲ/ Ⅳ ESCC admitted to Sichuan Cancer Hospital from March 2012 to November 2018. The pre-treatment HALP score was calculated
and the optimal cutoff value was determined using X - tile. The correlation between HALP and clinicopathological features was
analyzed. Prognostic factors were assessed using the Kaplan-Meier method and Cox regression models. A nomogram was constructed
and its predictive performance was validated. Result The low HALP group was significantly associated with more advanced T stage N
stage and clinical stage P < 0. 05 . The high HALP group showed significantly better 1- 3- and 5-year overall survival rates
compared to the low HALP group 74. 7% vs 54. 0% 46. 6% vs 25. 6% 36. 9% vs 19. 8% P < 0. 001 . Multivariate Cox
proportional hazards regression model analysis identified drinking history T stage and HALP as independent prognostic factors for
overall survival P < 0. 05 . The nomogram model for predicting overall survival had a C - index of 0. 687 demonstrating good
predictive performance and calibration plots indicated high predictive accuracy. Conclusion A low pre-treatment HALP score is an
independent poor prognostic factor for overall survival in ESCC patients undergoing radical radiotherapy. The HALP-based nomogram
model may provide a reference for individualized prognostic assessment.
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| Cite this article: |
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1Zhang Xue,1 Xiao Ling,2 Zheng Xiumei, et al. The predictive value of the pre - treatment hemoglobin albumin lymphocyte and platelet score for the prognosis of
radiotherapy in esophageal squamous cell carcinoma[J]. Electron J Metab Nutr Cancer, 2025, 12(6): 730-738.
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| URL: |
| http://www.ejmnc.com//EN/ OR http://www.ejmnc.com//EN/Y2025/V12/I6/730 |
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