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| Research advances on bioactive components from Semen Ziziphi Spinosae and clinical applications of formula |
| Li Zengning, Guo Yan |
| Department of Clinical Nutrition The First Hospital of Hebei Medical University Hebei Key Laboratory of Nutrition and Health
Shijiazhuang 050030 Hebei China |
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Abstract Semen Ziziphi Spinosae ZSS a natural medicinal and edible plant with a long history of use contains diverse
phytochemicals such as saponins flavonoids alkaloids and fatty acids among which saponins e. g. jujubosides A and B have
been most extensively studied. These phytochemicals exhibit a wide range of biological activities including sedative - hypnotic
neuroprotective anti-inflammatory antioxidant antiarrhythmic antiplatelet aggregation lipid-lowering antitumor hypoglycemic
and metabolic regulatory effects. Bioactive components of ZSS have demonstrated health-promoting functions such as improving sleep
alleviating anxiety and depression enhancing learning and memory modulating immunity and combating oxidative stress. Moreover
they show significant therapeutic potential across multiple disease models such as neurological disorders e. g. seizures Alzheimer
s disease Parkinson s disease cardiovascular diseases e. g. arrhythmias coronary atherosclerosis infections inflammatory
conditions malignancies e. g. lung breast and colorectal cancers and metabolic disorders e. g. diabetes polycystic ovary
syndrome . In recent years the application of traditional compound formulas and the development of new products using food-medicine
homologous substances have seen rapid progress. This review summarizes the pharmacology and underlying mechanisms of ZSS
bioactive components providing a reference for future scientific investigations. Current research and development of these bioactive
components remain at a preclinical stage necessitating further fundamental studies and clinical trials to validate their efficacy and
safety thereby facilitating in-depth exploration and utilization in healthcare applications.
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