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| Effect of the nutritional treatment model based on anti-inflammatory diet in patients undergoing breast cancer chemotherapy |
| Yang Jiangbo, Zhu Kuanmin, He Youxin, Wang Lei |
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Abstract Objective To explore the effect of nutritional therapy based on anti-inflammatory diet in breast cancer chemotherapy
patients and its effects on inflammatory indicators intestinal gate level dominant flora and adverse events. Method A total of 228
breast cancer chemotherapy patients admitted to Qinhuangdao Second Hospital from February 2021 to February 2024 were selected as
the study objects They were divided into two groups according to the random number method. 114 patients in the control group
received routine nutritional support and 114 patients in the observation group received nutritional treatment based on anti-inflammatory
diet. Compare the inflammatory factor levels leukocyte- 1β IL- 1β tumor cytokines TNF - α C reactive protein CRP
immune function CD8
+
T cells CD4
+
T cells CD3
+
T cells nutritional status index body mass index BMI upper arm
circumference MAC triceps skinfold thickness TF serum nutrition index prealbumin PA albumin Alb total protein
TP dominant flora Firmicutes antibacteria AFP at the same time The occurrence of adverse events during hospitalization was
statistically analyzed in two groups. Result After 14 days of intervention the levels of IL-1 β TNF - α CRP CD8
+
T cells BMI
MAC TSF and the logarithm of Firmicutes and Actinobacteria in both groups were lower than before intervention. The levels of CD4
+
T cells CD3
+
T cells PA Alb TP and the logarithm of Bacteroidetes and Actinobacteria were higher than before intervention in the
same group and the differences were statistically significant P < 0. 05 . At the same time after 14 days of intervention the
intervention group showed better improvement in IL-1 β TNF - α CRP CD8
+
T cells CD4
+
T cells CD3
+
T cells PA Alb and
TP compared to the control group and the difference was statistically significant P<0. 05 . BMI MAC TSF and the composition of
Firmicutes and Actinobacteria were lower in the intervention group compared to the control group and the difference was statistically
significant P<0. 05 . The composition of Bacteroidetes and Actinobacteria was higher in the intervention group compared to the control
group and the difference was statistically significant P<0. 05 . Meanwhile the adverse events in the intervention group 6. 14% vs 14. 91% were lower than those in the control group and the difference was statistically significant P<0. 05 . Conclusion Nutritional
therapy based on anti-inflammatory diet is more feasible safe and scientific. It is used in breast cancer chemotherapy patients to better
reduce inflammation improve body immune function improve nutritional status and promote the overall health recovery. It is of great
significance for clinical treatment guidance and prognosis improvement and has high utilization value.
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