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| Study on the relationship between dietary branched-chain amino acid intake and glucose lipid metabolism in patients with
colorectal cancer |
| 1,2Wang Ying,2Xue Hongmei,2Xie Ying,1,3Li Zengning |
| 1
School of Public Health Hebei Medical University Shijiazhuang 050000 Hebei China
2Department of Clinical Nutrition the First
Hospital of Hebei Medical University Hebei Key Laboratory of Nutrition and Health Shijiazhuang 050031 Hebei China
3Hospital of
Stomatology Hebei Medical University Shijiazhuang 050017 Hebei China |
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Abstract Objective To investigate the relationship between dietary branched-chain amino acid intake and glycolipid indices in
patients with colorectal cancer in order to provide a theoretical basis for ameliorating glycolipid metabolism disorders in patients.
Method Colorectal cancer patients were selected according to the inclusion and exclusion criteria from the databases of the Multicentre
Study on Nutritional Status and Clinical Outcomes of Common Malignant Tumors in China INSCOC study and the Current Status of
Dietary Intake and Its Influencing Factors in Patients with Common Malignant Tumors. Dietary questionnaires general information
laboratory indicators and other data were collected and analyzed using multiple linear regression and multifactorial Logistic
regression. Result The results of the multiple linear regression analysis revealed that the average daily intake of branched-chain amino
acids BCAA in the diet could significantly and negatively predict the levels of fasting blood glucose FPG total cholesterol TC
and high - density lipoprotein cholesterol HDL - C . Abnormal total cholesterol and abnormal abnormal high density lipoprotein
cholesterol HDL-C . Multivariate Logistic analysis showed that moderate and high intakes of various branched-chain amino acids in
the diet were protective factors for the occurrence of FPG abnormalities. After adjusting for confounding the risk of abnormal TC was
2. 07 times higher in the moderate daily leucine intake group than in the low intake group and the protective factor was the moderate
and high daily dietary branched-chain amino acid intake group. Triglyceride TG abnormalities were a protective factor in the medium and high daily intake groups of leucine and valine. The higher daily intake of isoleucine was the protective factor. Average daily intake
of branched - chain amino acids was a protective factor for HDL - C abnormalities. The risk of abnormal low density lipoprotein
cholesterol LDL-C was 3. 60 times higher in the moderate daily intake group than in the low intake group. Conclusion The results of
this study suggest that a higher intake of branched - chain amino acids is more likely to be a protective factor for abnormalities of
glycolipid metabolism in colorectal cancer patients with the moderate - intake group of AVG - Leu being a risk factor for TC
abnormalities and the moderate-intake group of AVG-BCAA being a risk factor for LDL-C abnormalities.
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| [1] |
Liu Jianrong, Qi Bing, Yang Xueni, Deng Wenjuan, Zhou Miao, Chen Yulin, Wang Duo, Zou Hao, Liu Huiling. The influence of multimodal pre-rehabilitation intervention based on the three-level diagnostic model of malnutrition on
patients with colorectal cancer[J]. Electron J Metab Nutr Cancer, 2025, 12(1): 76-82. |
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