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| Exploration of the clinical relationship between tumor heterogeneity and evaluation of radiotherapy and chemotherapy
efficacy in rectal cancer by magnetic resonance functional imaging analysis |
| Duan Yanhua, Yu Yudong, Deng Xiaoyan |
| Department of Medical Imaging Huizhou Central People's Hospital Huizhou 516000 Guangdong China |
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Abstract Objective Overall tumor assessment such as histogram analysis was a common means to obtain tumor heterogeneity
information that may affect the treatment response. The purpose of this study was to evaluate the role of functional magnetic resonance
imaging MRI in analyzing tumor heterogeneity in evaluating the efficacy of radiotherapy and chemotherapy CRT for rectal
cancer. Methods From January 2020 to November 2021 60 patients with locally advanced rectal cancer LARC who underwent MRI
examination before CRT in our hospital were selected as the research subjects. The apparent diffusion coefficient ADC intra-voxel
incoherent motion Dslow Dfast and F and stretch index model DDC and α were obtained from the histogram of the whole
tumor. Histogram indexes and prognostic factors before CRT were compared between patients with complete pathological remission
pCR and those without pCR. The receiver operating characteristic curve ROC curve was constructed to evaluate the diagnostic
performance of these parameters. Results After CRT treatment 13 patients 21. 7% were classified as pCR group while the other 47
patients were classified as non-pCR group 78. 3% . Compared with the pCR group the non-pCR group had significant differences in
tumor volume TRG and pT stages P < 0. 05 . The mean standard deviation and the 10th 25th 50th 75th 90th and 95th
percentile of ADC in pCR group were significantly lower than those in non-pCR group P<0. 05 . The mean skewness kurtosis and
25th 50th 75th 90th and 95th percentile of DDC in pCR group were lower than those in non-pCR group P<0. 05 . In ADC its
average value AUC = 0. 890 P<0. 001 95%CI = 0. 806-0. 974 had the highest diagnostic performance. In DDC its average
AUC = 0. 866 P<0. 001 95%CI = 0. 771-0. 960 has the highest AUC value. Average ADC combined with tumor volume had the
highest diagnostic performance in predicting pCR with AUC of 0. 932 sensitivity of 100% and specificity of 81%. Conclusion The
whole-tumor ADC mean combined with the tumor volume can effectively predict the response of LARC to CRT.
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| Cite this article: |
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Duan Yanhua,Yu Yudong,Deng Xiaoyan. Exploration of the clinical relationship between tumor heterogeneity and evaluation of radiotherapy and chemotherapy
efficacy in rectal cancer by magnetic resonance functional imaging analysis[J]. Electron J Metab Nutr Cancer, 2024, 11(6): 790-796.
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| URL: |
| http://www.ejmnc.com//EN/ OR http://www.ejmnc.com//EN/Y2024/V11/I6/790 |
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