Research progress on amino acid metabolism in tumor microenvironment
1Xue Yaqi,2Qin Liqiang,3Zhang Jianwei
1Department of Clinical Nutrition the First Affiliated Hospital of Soochow University Suzhou 215000 Jiangsu China
2Department of
Nutrition and Food Hygiene School of Public Health Soochow University Suzhou 215123 Jiangsu China
3Clinical Nutrition
Department Suzhou Hospital Affiliated to Nanjing Medical University Suzhou 215002 Jiangsu China
Abstract The tumor microenvironment is a complex system composed of non-tumor host cells around tumor cells non-cellular
components vascular system and soluble products which plays an important role in the initiation and progression of tumor.
Components in the tumor microenvironment as therapeutic targets for tumors have attracted extensive research interest. Amino acids
are the substrates for protein synthesis and are a vital source of energy and nutrients. More and more evidence indicates that amino acid
metabolism affects tumor growth metastasis and other biological processes through the regulation of tumor microenvironment and is
closely related to tumor immunity and drug resistance. At present dietary therapies targeting amino acid metabolism including
inhibition of amino acids transporter activity regulation of amino acids biosynthesis and amino acids modified dietary have had
remarkable achievements however there are still many problems to be solved. In this paper the effects of amino acid metabolism on
immune cells tumor - associated fibroblasts and other components in tumor microenvironment were reviewed and studies about
targeting amino acid metabolism for tumor therapy in recent years were summarized. We are aimed at providing research basis for better
therapy increased therapeutic effect and less drug resistance.
