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| Research progress on the anti-tumor mechanism of ketogenic diet |
| Zhang Li, Li Xiaoxue, Shu Qing, Tang Yuan |
| Neurological Surgery Sichuan Clinical Research Center for Cancer Sichuan Cancer Hospital & Institute Sichuan Cancer Center
Affiliated Cancer Hospital of University of Electronic Science and Technology of China Chengdu 610041 Sichuan China |
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Abstract As a common disease endangering human health cancer has a high prevalence and disease burden in the world. At
present surgery and chemoradiotherapy are the main treatment options for tumor. For early or locally advanced tumors surgery can
remove the tumor completely providing the opportunity for radical treatment. Chemoradiotherapy has a good effect on local tumor
control. However the efficacy of single operation chemoradiotherapy or combined operation with chemoradiotherapy may be limited by
the drug resistance and clinical stage of patients and adjuvant therapy should be actively sought clinically. In recent years tumor
metabolism and tumor nutrition have become the focus of clinical anti -tumor research. Ketogenic diet is a high fat and low sugar
formula diet with reasonable proportion of protein and other nutrients which is widely used in the clinical treatment of brain diseases
and metabolic diseases. Neoplasms can be regarded as metabolic diseases. On the one hand ketogenic diet therapy for tumor patients
can satisfy the survival energy of normal cells on the other hand due to the restriction of ketone body utilization of tumor cells it can
effectively inhibit their growth and metabolism and thus play an anti-tumor role. At present ketogenic diet can play an anti-tumor
role by reducing glucose level inducing oxidative stress improving mitochondrial ketogenic body metabolism anti-inflammatory and
enhancing immunity and other mechanisms. This article reviews the anti-tumor mechanism of ketogenic diet and the recent clinical
research progress.
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