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| Correlation between prognostic nutritional index and insulin resistance in male patients with fatty liver disease |
| 1,2Jiang Qilan ，1,2Su Wenyi ，1,2Han Ming ，1,2Liao Xin ，2Luo Gang ，1,3Wang Min |
| 1Department of Clinical Nutrition the Affiliated Hospital of Southwest Medical University Luzhou 646000 Sichuan China
2Department of Gastroenterology the Affiliated Hospital of Southwest Medical University Luzhou 646000 Sichuan China
3Hemodynamics and Medical Engineering Combination Key Laboratory of Luzhou Luzhou 646000 Sichuan China |
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Abstract Objective To investigate the correlation between prognostic nutritional index PNI and insulin resistance IR in male
patients with fatty liver disease and to provide a scientific basis for the clinical management of patients with fatty liver disease.
Method A cross-sectional survey Method was used to analyze the data from male individuals who underwent health examinations at the
Health Management Center of the Affiliated Hospital of Southwest Medical University between January 2019 to December 2021 and
fatty liver was diagnosed based on abdominal ultrasound results. IR was defined according to the triglyceride-glucose index TyG and
PNI scores were categorized into tertiles Q1 PNI < 55. 36 Q2 55. 36 ≤ PNI < 58. 56 Q3 PNI ≥58. 56 . Logistic regression
analysis was employed to examine the association between PNI and IR with the Q1 group serving as the reference. Result A total of
714 male patients with fatty liver were included in this study of which 490 had IR 68. 63% . The results of univariate and multivariate
logistic regression analysis showed that PNI is a risk factor for IR in male patients with fatty liver disease. Univariate logistic regression
analysis compared with the PNI < 55. 36 group the risk of IR when PNI levels were 55. 36 ≤ PNI < 58. 56 and PNI ≥ 58. 56
increased by 1. 717 times and 2. 264 times greater respectively. Multivariate logistic regression analysis after adjusting for
confounding factors such as body mass index waist circumference visceral fat area and total cholesterol compared with the PNI <
55. 36 group the risk of IR when PNI levels were 55. 36≤ PNI < 58. 56 and PNI≥58. 56 increased by 1. 694 and 1. 710 times
respectively. Conclusion PNI may serve as a useful indicator for assessing the risk of IR in male patients with fatty liver and may
potentially be a predictor of IR onset.
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