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| The relationship between lymphocyte-to-C-reactive protein ratio and prognosis in patients with non-small cell lung cancer |
| 1Liu Yan, 2Peng Simin, 3Yang Jinrong, 4Zhang Yusong, 1Chen Guochong, 1Qin Liqiang |
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School of Public Health Suzhou Medical College of Soochow University Suzhou 215123 Jiangsu China
2Preventive Medicine
Department Dongguan People's Hospital Dongguan 52300 Guangdong China
3Health Department Wu Zhong District Disease
Prevention and Control Center Suzhou 215123 Jiangsu China
4Oncology Department Second Affiliated Hospital of Soochow
University Suzhou 215123 Jiangsu China |
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Abstract Objective Systemic inflammatory response is closely related to tumor progression. We aimed to investigate the
prognostic value of ratio of lymphocyte to C-reactive protein ratio LCR for overall survival OS in patients with non-small cell lung
cancer NSCLC . Method 422 NSCLC patients were enrolled in this study. An outcome-oriented Method was used to determine the
most appropriate cut - off value of LCR. The participants were divided into two groups a low - LCR group and a high - LCR
group. Survival curves were generated using the Kaplan-Meier Method and compared using the log-rank test. We performed subgroup
analysis according to histological type adenocarcinoma vs squamous cell carcinoma and TNM stage Ⅰ-Ⅲ vs Ⅳ . Cox proportional
hazard regression model was used to calculate hazard ratio HR and 95% confidence interval CI . Moreover We performed subgroup
analysis and interaction analysis based on patient characteristics and Cox product interaction analysis to investigate the impact of the
interaction between patient characteristics and LCR on the prognosis of NSCLC patients. Result The Kaplan-Meier analysis revealed
that patients with high LCR had significantly improved OS P<0. 001 . Patients with high LCR also showed a significantly improved OS
P<0. 001 after stratified by histological type and TNM stage. The Cox multivariate analysis showed that patients with high LCR
HR= 0. 45 95%CI = 0. 34-0. 61 P<0. 001 had favorable prognoses when compared with those with the lowest LCR. Gender P =
0. 012 smoking P= 0. 002 and histological type P = 0. 012 significantly interacted with LCR indicating that high LCR was a
good indicator for male former/ current smokers squamous carcinoma or adenocarcinoma patients. Conclusion High LCR may be
associated with a favorable prognosis in NSCLC patients.
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