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| Research progress of purinergic receptors in tumors |
| Yang Xue, Deng Licong, Wan Shan |
| Department of Oncology the First People?? s Hospital of Ziyang Ziyang 641300 Sichuan China |
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Abstract Purinergic signaling is involved in many biological processes. Adenosine 5′ - triphosphate and other extracellular
nucleotides act as endogenous ligands to bind and activate purinergic receptors for signaling and indicate their potential. A variety of
widely expressed purinergic receptors have been found in human tumor tissues and tumor cell lines which are activated by extracellular
ATP in inflammatory and hypoxic tumor environments and play a key role in affecting tumor cell metabolism proliferation and
metastasis. Specifically P2X receptors belong to ligand - gated ion channels while P2Y receptors belong to G protein - coupled
receptors. Activation of these receptors affects key biological processes such as intracellular Ca
2+
concentration cell cycle apoptosis
and cell migration. In different types of tumors different purinergic receptor subtypes show different expressions and effects. For
example P2X7 promotes tumor cell proliferation in neuroblastoma while P2Y12 inhibits tumor cell clonogenicity and migration in
glioblastoma. In addition the activation of purinergic receptors also affects the immune response and therapeutic effect in the tumor
microenvironment. Drugs targeting different purinergic receptor subtypes can affect the growth and metastasis of tumor cells and even
enhance the effect of immunotherapy. This article reviewed the functional research progress of a variety of purinergic receptors and
discussed their roles in different cancers and further understand its potential as a target for anti-tumor drugs.
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Received: 08 April 2024
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