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| Research progress on the role of M2 type pyruvate kinase glycolipid metabolism key enzymes in metabolic reprogramming of
malignant tumors |
| 1Chen Yekai,1Li Hegen,2Zhao Tiancheng,1Zhu Lihua,1Zhou Lei |
| 1
Longhua Hospital Shanghai University of Traditional Chinese Medicine Shanghai 200032 China
2
Shanghai 6
th People′s Hospital
Shanghai 200032 China |
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Abstract Metabolic reprogramming is one of the important features of tumors which provides essential macromolecules for
adenosine triphosphate ATP and intracellular protein and nucleotide biosynthesis thereby promoting the proliferation and survival of
tumor cells. The metabolism of tumor cells is significantly different from that of normal cells and the strong plasticity of tumors is an
important reason for the slow progress of targeted tumor metabolic therapy research. Research has shown that key metabolic enzymes in
glucose and lipid metabolism can alter their own activity and obtain non metabolic enzyme functions in various ways thereby driving
metabolic reprogramming in tumor cells. These methods mainly include abnormal protein expression mutations post - translational
modifications changes in oligomeric state and subcellular translocation. Pyruvate kinase is a key enzyme in the cellular glycolytic
pathway which catalyzes the conversion of phosphoenolpyruvate to pyruvate and produces adenosine triphosphate. M2 type pyruvate
kinase PKM2 can promote tumor cell proliferation and synthetic metabolism by enhancing the Warburg effect. It can also enter the
nucleus as a co transcription factor and protein kinase to regulate gene transcription playing an important role in malignant tumor
metabolic remodeling cell proliferation and metastasis. This article summarizes the abnormal expression of PKM2 in various types of
tumors its role and mechanism in tumor metabolism regulation and its application and breakthroughs in the field of traditional Chinese
medicine in order to provide new ideas for clinical tumor metabolism therapy.
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Received: 29 March 2024
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| Cite this article: |
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1Chen Yekai,1Li Hegen,2Zhao Tiancheng, et al. Research progress on the role of M2 type pyruvate kinase glycolipid metabolism key enzymes in metabolic reprogramming of
malignant tumors[J]. Electron J Metab Nutr Cancer, 2024, 11(4): 571-575.
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| URL: |
| http://www.ejmnc.com//EN/ OR http://www.ejmnc.com//EN/Y2024/V11/I4/571 |
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