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| Construction the GLIM criteria - based predictive model for nutritional deterioration in patients with malignant tumors
undergoing radiotherapy |
| Chen Qiao, Gao Mingyue, Yuan Meirui, Zhang Xiaodan, Liu Chen |
| Department of Radiotherapy Air Force Medical Center the Fourth Military Medical University of the Chinese People′s Liberation Army
Beijing 100142 China |
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Abstract Objective To investigate the nutritional status of cancer patients undergoing radiotherapy using the Global Leadership
Initiative on Malnutrition GLIM criteria and establish a predictive model for post-radiotherapy nutritional deterioration. Method A
total of 97 hospitalized cancer patients who received radiotherapy at the Fourth Military Medical University of the Chinese People′s
Liberation Army from January 2022 to December 2022 were selected. The GLIM criteria for malnutrition were applied before
radiotherapy and patients were categorized into stable nutrition n = 57 or deteriorated nutrition groups n = 40 based on whether they
experienced more than a 5% body weight loss after radiotherapy. Univariate and multivariate Logistic regression analysis was conducted
to identify factors influencing nutritional deterioration during hospitalization and a nomogram prediction model was developed based on
these factors. Discrimination AUC Hosmer-Lemeshow test and decision curve analysis DCA were used to assess the model′s
accuracy and clinical utility. Result Among the 97 patients 38 39. 1% had nutritional risk or malnutrition while 40 41. 2%
experienced nutritional deterioration following radiotherapy. There were no significant differences in age gender education level
tumor location underlying diseases distant metastasis or BMI at admission between the two groups. Univariate and multivariate logistic
regression analyses revealed that GLIM malnutrition status radiotherapy frequency and prealbumin levels independently predicted
nutritional deterioration after radiotherapy P < 0. 05 . The nomogram model demonstrated an AUC value of 0. 723 95% CI =
0. 622-0. 825 with good calibration curves observed for both validation data sets as well as ideal curves in terms of discrimination
ability. Conclusion The GLIM criteria is an effective tool for predicting the deterioration of nutritional status in tumor patients after
radiotherapy. The nomogram model constructed based on the GLIM evaluation radiotherapy frequency and prealbumin levels can
effectively predict the risk of nutritional deterioration in patients after radiotherapy. This provides valuable guidance and reference for
medical staff in the radiotherapy department to implement proactive preventive nursing interventions.
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Received: 23 February 2024
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| Cite this article: |
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Chen Qiao,Gao Mingyue,Yuan Meirui, et al. Construction the GLIM criteria - based predictive model for nutritional deterioration in patients with malignant tumors
undergoing radiotherapy[J]. Electron J Metab Nutr Cancer, 2024, 11(4): 540-546.
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| URL: |
| http://www.ejmnc.com//EN/ OR http://www.ejmnc.com//EN/Y2024/V11/I4/540 |
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