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| Clinical effect of high-dose vitamin C combined with FOLFOX6 for colorectal cancer |
| 1Sun Longfeng,1Wang Zhichao,1Dai Meng,2Fan Yueping,3Rao Benqiang |
| 1Department of Digestive Surgery Gastroenterology Centre Aviation General Hospital Beijing 100012 China
2General Surgery
Aviation General Hospital Beijing 100012 China
3Center for Oncology Nutrition and Metabolism Beijing Shijitan Hospital Capital
Medical University / Key Laboratory of Cancer FSMP for State Market Regulation Beijing 100038 China |
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Abstract Objective To investigate the clinical effect of high-dose vitamin C combined with FOLFOX6 chemotherapy for colorectal
cancer. Method The clinical data of 58 patients with colorectal cancer admitted to Aviation General Hospital from April 2016 to
September 2017 were retrospectively analyzed. According to the treatment methods they were divided into experimental group treated
with high - dose vitamin C combined with FOLFOX6 chemotherapy n = 29 cases and control group treated with FOLFOX6
chemotherapy alone n = 29 cases . The effects of treatment adverse reactions and improvements in patients′ quality of life were
compared between the two groups. Result The effective rate was 58. 6% in the experimental group and 44. 8% in the control group with
statistically significant differences P<0. 05 . After treatment tumor marker carcinoembryonic antigen and tumor marker carbohydrate
antigen 19-9 concentrations in 2 groups were significantly decreased after treatment P<0. 05 and the decrease in experimental group
was more obvious than control group P<0. 05 . The adverse reactions of digestive tract reaction and bone marrow suppression were
significantly reduced in the experimental group and the differences between the two adverse reactions were statistically significant P<
0. 05 . The improvement rate of experimental group was 62. 06% which was significantly higher than that of control group 48. 27%
and the difference was statistically significant P< 0. 05 . Conclusion Compared with FOLFOX6 chemotherapy alone high - dose
vitamin C combined with FOLFOX6 chemotherapy in the treatment of colorectal cancer can achieve significant clinical efficacy reduce
the adverse reactions of chemotherapy and improve the quality of life of patients which has high clinical value.
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Received: 23 December 2032
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