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| Research progress of microbiome and its metabolites regulating brain glioma |
| Liu Li, Wang Ran, Zhang Qi |
| Research Center for Probiotics Department of Nutrition and Health China Agricultural University Beijing 100093 China |
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Abstract Gliomas are the most common brain tumors accounting for 80% of malignant brain tumors of which glioblastoma
multiforme is the most aggressive type of glioma and is one of the refractory tumors in the world. At present the main treatment for
glioblastoma is surgery which has great side effects easy recurrence and low survival rate. Therefore seeking more potential
biomarkers and improving survival rate remain important challenges in glioma research. There is growing evidence that the intratumoral
and gut microbiome play an important role in glioma progression and treatment response and that specific microbiome is associated with
different stages of tumor progression. In the meantime the interactions and mechanisms between the metabolites and the central nervous
system have received extensive attention. However the correlation between the microbiome metabolites and glioma remains
unclear. This review focuses on the relationship between the glioma intratumoral microbiome intestinal microbiome and their
metabolites such as amino acids including tryptophan arginine glutamate short-chain fatty acids neurotransmitters. And the
improvement effect of probiotics on glioma was summarized so as to provide relevant basis for early prediction and treatment of glioma
based on the microbiome.
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Received: 04 February 2023
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