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| Association of FOXP3
+
tumor infiltrating lymphocytes with poor prognosis of primary breast cancer a retrospective
cohort study |
| Zhao Xia, Li Yanping, Feng Yu, Lyu Shuzhen |
| Department of Surgical Breast Cancer Capital Medical University Cancer Center Beijing Shijitan Hospital Capital Medical University
Beijing 100038 China |
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Abstract Objective To detect the expression of FOXP3
+
TILs in primary invasive breast cancer analyze the correlation between
the expression level of FOXP3
+
TILs and the clinicopathological characteristics of breast cancer and explore the relationship between
FOXP3
+
TILs and the prognosis of breast cancer. Method Surgically resected samples from 156 patients with invasive breast cancer
BC were assessed for the expression of FOXP3
+
TILs and CD4
+
TILs by immunohistochemistry. The correlation between FOXP3
+
TILs
and the patients ' clinicopathological characteristics was explored. Kaplan - Meier survival analysis and Cox proportional hazards
regression model were used to assess the correlation between FOXP3
+
TILs and breast cancer-specific survival and to stratify the
evaluation of breast cancer subtypes. Result Elevated FOXP3
+
TILs infiltration were significantly correlated with high histological grade
P= 0. 021 positive human epidermal growth factor receptor-2 HER-2 P=0. 018 Progesterone receptor expression PR P=0. 016
high Ki-67 index P = 0. 042 and axillary lymph node metastases P = 0. 001 . There was no significant correlation between CD4
+
TILs
expression and the clinicopathological features of all patients. Tumors with concomitant high expressions of FOXP3
+
TILs had worse overall
survival OS and disease-free survival DFS 64. 7% vs 87. 6%
χ
2 = 15. 3 P<0. 001 56. 9% vs 80. 0%
χ
2 = 13. 1 P<0. 001 . The patients
with axillary lymph node metastases with the high expressions of FOXP3
+
TILs infiltration had worse DFS P<0. 001 . Multivariate analysis
showed that FOXP3
+
TILs was independent predictors of OS HR=2. 732 95%CI=1. 174~6. 207 P=0. 023 and DFS HR=2. 092 95%CI=
1. 068~4. 088 P = 0. 032 . Conclusion The high expression of FOXP3
+
TILs in breast cancer is associated with tumor progression higher
expression of FOXP3
+
TILs indicates wores OS and DFS FOXP3
+
TILs maybe a prognostic marker for breast cancer.
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