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Abstract Objective To evaluate the nutrition status in patients with hematopoietic stem cell transplantation HSCT and its
influence on prognosis. Method Clinical data from 68 patients with hematopoietic stem cell transplantation was collected. The body
weight body mass index BMI biochemicals and other nutrition-related indexes were monitored before transplantation and 14 days
30 days 60 days and 90 days after transplantation and their correlation with acute graft versus host disease aGVHD and clinical
outcomes were analyzed. Result Patients are at risk of malnutrition after transplantation ① BMI of patients exhibited a significant
decrease after transplantation compared to the pre - transplantation in particular BMI at 90 days after transplantation decreased
dramatically P<0. 05 ②Albumin and prealbumin decreased significantly in the early stage after transplantation and increased in the
late stage of transplantation compared with the early stage P<0. 05 ③After transplantation triglyceride was significantly higher than
before transplantation and high-density lipoprotein cholesterol was significantly lower than before transplantation P<0. 05 . The blood
glucose and triglycerides of patients with aGVHD after transplantation were higher than those without aGVHD P<0. 05 The albumin
and prealbumin of the aGVHD group after transplantation were lower than those without aGVHD group P< 0. 05 . Patients in the
survival group had higher amounts of albumin and total protein than those in the non - survival group P < 0. 05 . Conclusion The
nutrition status of patients receiving hematopoietic stem cell transplantation can be assessed by using body composition and biochemical
indexs. Patients with aGVHD have a worse nutritional state than patients without aGVHD while those with good nutritional status have
a better prognosis than those with poor nutritional status.
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Corresponding Authors:
张彦明,电子邮箱:zhangyanming2005@ 126. com
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