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| Research progress on related factors of pathogenesis for cancer anorexia |
| 1Wei Xinxin ,2Qi Shujing,3Zhang Yong,3Qi Ruixia |
| 1Department of Nephrology and Endocrinology Handan Hospital of Traditional Chinese Medicine Handan 056000 Hebei China
2Department of Nutrition Affiliated Hospital of Hebei University of Technology Handan 056001 Hebei China
3
School of Chemical
and Pharmaceutical Engineering Hebei University of Science & Technology Shijiazhuang 050018 Hebei China |
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Abstract Cancer anorexia can appear throughout the disease of cancer patients and is often ignored. The disease is common in
advanced cancer patients with an incidence of up to 80%. Cancer anorexia is related to the chronic disease or anti-cancer treatment of
cancer patients with characters of loss of appetite with or without weight loss negatively affects quality of life and even cancer
anorexia-cachexia syndrome which directly affects the survival outcome of patients. Modern medical research believed that cancer
anorexia is caused by the failure of normal appetite regulation signal transduction and different from malnutrition or hunger it is
caused by metabolic abnormalities. However the current research on the pathogenesis of cancer anorexia has not been completely
clear. Most studies believed that pro-inflammatory cytokines such as interleukin-1 tumor necrosis factor-α and interleukin-6 and
peripheral hormones such as ghrelin leptin and cholecystokinin central neuropeptide can alter normal regulation signals that govern
appetite in different ways and then lead to cancer anorexia. Herein we aimed to review the recent related factors of pathogenesis progress
for cancer anorexia and can provide references for further research on evaluation of cancer anorexia and new therapeutic targets.
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