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| Progress in the pathogenesis diagnosis and treatment of sarcopenic obesity |
| Zhai Xingyue,Han Yunyan,Zhou Yun |
| Clinical Nutrition Department The Second Hospital of Dalian Medical University Dalian 116023 Liaoning China |
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Abstract Sarcopenic obesity is a clinical state in which the co - existence of obesity and sarcopenia. In the co - existence of
sarcopenia and obesity the lean body mass is unbalanced with the fat content. Which is associated with adverse clinical outcomes. Both
sarcopenia and obesity have independent adverse effects on health and the synergistic effect of both leads to increased metabolic
disorders making the health problems brought by sarcopenia obesity far more serious than that of sarcopenia or obesity alone. Early and
effective intervention measures can prevent treat and delay the progression of sarcopenic obesity. Therefore early screening
diagnosis and treatment are particularly important. The treatment measures for sarcopenic obesity mainly include nutrition and exercise
intervention and new drug therapy or intestinal flora therapy also have a certain effect on sarcopenic obesity. In recent years research
on sarcopenic obesity has made certain progress. The European Society for Clinical Nutrition and Metabolism and the European
Association for Obesity Research have published diagnostic criteria to clarify their diagnosis for the first time the pathogenesis of
sarcopenic obesity and the complex interaction between metabolic disorders and inflammation have been further revealed but there is
still no specific treatment for sarcopenic obesity. This paper reviews the diagnostic criteria molecular mechanisms and treatment
progress of sarcopenic obesity providing reference for the prevention treatment and clinical research of sarcopenic obesity.
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Received: 12 April 2023
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