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| NLR combined with PLR predicted muscle mass loss in patients with primary liver cancer |
| 1 Ni Peiping,1 Chen Li,1 Wu You,2Lyu Muhan,1Wang Min |
| 1Department of Clinical Nutrition The Affiliated Hospital of Southwest Medical University Luzhou 646000 Sichuan
China
2Cardiovascular and Metabolic Diseases Key Laboratory of Luzhou Luzhou 646000 Sichuan China
3Department of
Gastroenterology The Affiliated Hospital of Southwest Medical University Luzhou 646000 Sichuan China |
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Abstract Objective To investigate the relationship between neutrophil to lymphocyte ratio NLR platelet to lymphocyte ratio
PLR and muscle mass loss in patients with primary liver cancer. Method 328 primary liver cancer patients were included in a
retrospective study. Cross sectional skeletal muscle index SMI of the third lumbar vertebra was Computed with Computed Tomography
CT . The risk factors of muscle loss were analyzed by Logistic regression and the optimal cut-off values of NLR and PLR were
determined according to receiver operating characteristics ROC curve. The area under the curve AUC was used to evaluate the
predictive effect of each indicator on muscle loss in primary liver cancer patients. Result 328 primary liver cancer patients included 269
male patients and 59 female patients and the incidence of total muscle mass loss was 61. 89%. ROC curve showed that the optimal
cut-off values of NLR and PLR were 4. 04 and 163. 01 respectively and the AUC values were 0. 629 95%CI = 0. 569-0. 690 P <
0. 001 0. 608 95%CI = 0. 546- 0. 670 P = 0. 001 the AUC value of primary liver cancer muscle mass loss predicted by NLR
combined with PLR was 0. 643 which was better than that predicted by NLR and PLR alone. NLR combined with PLR score 0 score
NLR≤4. 04 and PLR≤163. 01 Score NLR > 4. 04 or PLR > 163. 01 2 scores NLR > 4. 04 and PLR > 163. 01 could further
stratify the loss of muscle mass in primary liver cancer patients and the difference between groups was statistically significant χ2 =
24. 262 P < 0. 001 . Conclusions NLR and PLR are independent predictors of muscle mass loss in primary liver cancer patients and
their combination is more likely to identify primary liver cancer patients with muscle mass loss.
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Received: 03 February 2022
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