Study on the correlation between nutrition‑related symptoms GLIM and quality of life in patients with colorectal cancer
1 Ruan Xiaoli, 1 Rena Nakyeyune, 1 Shen Yi, 2, 3 Shi Hanping, 1 Liu Fen
1 Department of Epidemiology and Health Statistics, School of Public Health, Beijing Municipal Key Laboratory of Clinical Epidemiology,
Capital Medical University, Beijing 100069, China; 2
Department of Gastrointestinal Surgery/Department of Clinical Nutrition, Beijing
Shijitan Hospital, Capital Medical University, Beijing 100038, China; 3
Key Laboratory of Cancer FSMP for State Market Regulation,
Beijing 100038, China
Abstract：Objective To evaluate the impact of nutrition⁃related symptoms on the nutritional status and its correlation with
Global Leadership Initiative on Malnutrition (GLIM) and quality of life. Method A total of 2063 patients with colorectal cancer re⁃
cruited in multicenters from June 2013 to December 2018 were included in this study, all of them completed malnutrition diagnosis
and evaluation of quality of life. Logistic regression analysis was used to evaluate the impact of nutrition⁃related symptoms on nutri⁃
tional status, and Spearman correlation analysis was used to assess the correlation between nutrition⁃related symptoms and GLIM,
quality of life. Result A total of 875 patients (42.4%) had at least one nutrition⁃related symptom, and the highest incidence was no
appetite (14.5%), 948 patients (45.5%) were malnourished. The median of QLQ⁃C30 score of 66.7.The results of Spearman correla⁃
tion analysis showed that except for mouth sores, no appetite (r=0.246, P<0.001), nausea (r=0.137, P<0.001), vomiting(r=0.154, P< 0.001), constipation (r=0.124, P<0.001), dry mouth (r=0.138, P<0.001), feel full (r=0.150, P<0.001), pain (r=0.175, P<0.001), the
score of nutrition-related symptoms (r=0.337, P<0.001) were correlated with malnutrition according to GLIM criteria. The associa⁃
tion between malnutrition diagnosed by GLIM criteria and diarrhea (r=0.072, P=0.001), change in taste (r=0.088, P<0.001), change
in smell (r=0.070, P=0.001), problems swallowing (r=0.049, P=0.025) was low, although statistically significant. The QLQ⁃C30 score was correlated with nutrition⁃related symptoms (except diarrhea) (no appetite:r=0.309, P<0.001; nause: r=0.209, P<0.001;
vomiting: r=0.189, P<0.001; constipation: r=0.138, P<0.001; mouth sores: r=0.077, P<0.001; dry mouth: r=0.157, P<0.001; change
in taste: r=0.157, P<0.001; change in smell: r=0.119, P=0.001; problems swallowing: r=0.104, P=0.025; feel full: r=0.115, P<0.001;
pain: r=0.154, P<0.001). No appetite, vomiting, constipation, diarrhea, dry mouth, feel full and pain were independent risk factors for
malnutrition after adjustment for age, type of cancer, stage, organ metastasis, and nutritional treatment (no appetite: HR=3.152,
95%CI=2.335-4.255, P<0.001; vomiting: HR=2.877, 95%CI=1.648-5.023, P<0.001; constipation: HR=1.796, 95%CI=1.283-2.516, P=0.001; diarrhea: HR=1.549, 95%CI=1.096-2.190, P=0.013; dry mouth: HR=2.252, 95%CI=1.454-3.488, P<0.001; feel full: HR= 3.317, 95%CI=2.102-5.235, P<0.001; pain: HR=2.346, 95%CI=1.628-3.379, P<0.001). Conclusion The prevalence of nutrition⁃re⁃
lated symptoms in patients with colorectal cancer is high, and it is related to the nutritional status and quality of life. Early assessment
of the occurrence of nutrition⁃related symptoms is beneficial to take appropriate treatment to improve the nutritional status and quali⁃
ty of life of patients.
1 阮晓莉，1 Rena Nakyeyune，1沈 艺，1 朱凌妍，2，3 石汉平，1刘 芬. 结直肠癌患者营养相关症状与GLIM和生活质量的相
关性研究[J]. 肿瘤代谢与营养电子杂志, 2022, 9(1): 39-48.
1 Ruan Xiaoli, 1 Rena Nakyeyune, 1 Shen Yi, 2, 3 Shi Hanping, 1 Liu Fen. Study on the correlation between nutrition‑related symptoms GLIM and quality of life in patients with colorectal cancer. Electron J Metab Nutr Cancer, 2022, 9(1): 39-48.
