Abstract：Objective To observe and evaluate the effect of combined β?hydroxy?methylbutyric acid (HMB) in blood purification patients with end?stage renal disease, to explore more effective methods and approaches to prevent and cure the disorder of calcium and phosphorus metabolism in end?stage renal disease. Methods From March 2018 to August 2019, 64 patients with end?stage renal disease who received blood purification, it was divided into experimental group and control group with 32 cases in each group, with random control design. Both groups were treated with routine blood purification. HMB intervention was performed in the trial group and placebo in the control group, which for a total duration of 12 weeks. To observe changes in laboratory indicators before and after treatment, including: serum calcium, phosphate, intact parathyroid hormone, urea nitrogen, serum creatinine, serum albumin and prealbumin, hemoglobin. Results (1)Laboratory results of calcium and phosphorus metabolism disorders: compared with pre?treatment, serum phosphorus and parathyroid hormone decreased after intervention in the experimental group, serum calcium elevated, the curative effect was better than the control group(P<0.05). (2) Results of renal function index: compared with pre?treatment, the serum Cr, BUN were decreased in the treatment group, and the curative effect was better than the control group(P<0.05). (3) Nutritional status indicators: compared with pre?treatment, the albumin and prealbumin increased after the intervention, the curative effect was better than the control group(P<0.05); There was no significant change between the experimental group and the control group before and after hemoglobin intervention (P>0.05). Conclusions Adding HMB, in blood purification patients with end?stage renal disease, it can effectively regulate the disorder of calcium and phosphorus metabolism, improve improve the renal function and the nutritional status of patients, and delay the occurrence of related complications.
梁清月，王仲，宗雪萍，刘菲，李轰烈. HMB对终末期肾病血液透析患者钙磷代谢紊乱的疗效观察[J]. 肿瘤代谢与营养电子杂志, 2021, 8(2): 179-183.
Liang Qingyue, Wang Zhong, Zong Xueping, Liu Fei, Li Honglie. Clinical study on the effect of HMB on disorder of calcium and phosphorus metabolism in blood purification patients with end?stage renal disease. Electron J Metab Nutr Cancer, 2021, 8(2): 179-183.
