冠状动脉粥样硬化病因病理及功能医学临床干预探讨

doi:10.16689/j.cnki.cn11-9349/r.2019.03.019

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摘要动脉粥样硬化是心血管疾病的主要病理变化。尽管心血管疾病病因病理十分复杂，涉及多种相关风险因素，但现有文献中已经基本接受动脉粥样硬化是一具有特征性氧化压力升高的炎性疾病。本文回顾和分析了近几十年来文献中的研究成果，梳理了复杂的心血管疾病风险因素，提出了一个动脉粥样硬化发生发展的全新的理论。由于氧化压力升高、维生素C不足、胶原合成等因素持续存在，以及这一不正常的动脉管壁修复机制的难以控制，最终导致粥样斑块的形成、管腔的狭窄、堵塞以及心肌缺血梗死。低碳医学倡导的健康饮食，最佳及个性化营养等在冠脉粥样硬化治疗及预防中起到主导作用。氧化压力升高而导致的抗氧化剂（尤其维生素C）耗竭，造成胶原蛋白合成障碍，进而引起临床疾病的机制并不限制于冠心病。这一现象也可见于骨质疏松等。这种氧化压力、抗氧化剂（维生素C）、胶原合成之间的动态变化具有较大的区域性。

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关键词 ：心血管疾病, 动脉粥样硬化, 维生素C

Abstract：Although the pathogenesis of CVD is very complicated and involves a variety of risk factors， it has been generally recognized and accepted in the literature that atherosclerosis is an inflammatory disease characterized by elevated oxidative stress. Sufficient basic research and preliminary clinical studies show that atherosclerosis is potentially reversible. Based on the review and analysis of decades of research， we propose a new theory of atherosclerosis development. Due to the continued and usually worsening presence of the increased oxidative stress， vitamin C deficiency， collagen synthesis deficiency and other pathogenic factors， this abnormal mechanism of arterial wall repair will not stop， which eventually leads to the formation of atherosclerosis plaque， resulting in arterial stenosis， occlusion and myocardial ischemia. Low carbohydrate diet promotes health， optimal and personalized nutrition and plays a leading role in the treatment and prevention of coronary atherosclerosis. In this paper， the mechanism of coronary heart disease is not limited to coronary heart disease due to the depletion of antioxidants (especially vitamin C) caused by the increase of oxidative pressure caused by toxin increase. This phenomenon can also be seen in osteoporosis. The dynamic changes among oxidative stress， antioxidants (vitamin C)， and collagen synthesis were regional.

Key words： Cardiovascular disease Atherosclerosis Vitamin C

通讯作者: 成长，电子邮箱：richzc@gmail.com

引用本文:

1成长， 2Thomas Levy . 冠状动脉粥样硬化病因病理及功能医学临床干预探讨[J]. 肿瘤代谢与营养电子杂志, 2019, 6(3): 365-369.
1CHENG， Richard Zhang， 2THOMAS Levy. Clinical intervention of coronary atherosclerosis in etiology， pathology and functional medicine. Electron J Metab Nutr Cancer, 2019, 6(3): 365-369.

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