Abstract：Objective To evaluate the effect of different levels of energy intake on nutritional status and quality of life in patients with head and neck cancer during radiochemotherapy. Methods Four items including nutritional assessment, dietary survey, measuring body composition and quality of life were employed to investigate 90 patients with head and neck cancer which meet the inclusion criteria in two periods, including the stage before radiochemotherapy and the end of radiotherapy. Dietary intake was estimated by a 24h dietary recall conducted by the oncology dietitian each time, including energy from food and oral nutritional supplements. Energy requirements were estimated by using Harris-Benedict equation, then the energy ratio was calculated. The proportion of energy intake<70% was group A, and the proportion of energy intake≥70% was group B. Results There were no significant differences in clinical data, including age, gender, BMI, nutritional status, clinical stage, dignosis, radiological dose
and treatment method between group A and group B (P>0.05), so the two groups were comparable. At the end of radiotherapy, the incidence of malnutrition in group A was significantly higher than group B, the incidence of malnutrition in group A and group B were 100% and 84.09%, respectively. According to 24h dietary recall, the energy intake from food and ONS in group A were 864kcal and 214kcal, respectively, which were significantly lower than group B (P<0.05). The influences on body compositions by energy intake were expressed by the changes before and after radiotherapy. The results showed that the changes of BMI, weight, muscle mass, protein, skeletal mass and percentage of body fat in group A were greater than in group B. All the changes beween two group had significant differences (P <0.05), besides the changes of protein and skeletal mass. Before radiotherapy, there were no significant
differences in life quality scores between two groups. However, at the end of the radiotherapy, the functional scores were lower in group A than in group B, the symptom scores are higher in group A than in group B. There were significant differences in the total quality of life, cognitive function, pain, fatigue, loss of appetite between two groups. Conclusions The nutritional status, body composition and life quality deteriorate for patients with head and neck cancer after radiochemotherapy. Nevertheless, maintaining the energy intake≥70% could prevent further deterioration.
龚丽青，王艳莉，孙艳. 能量摄入对头颈癌放化疗患者营养状况和生活质量的影响[J]. 肿瘤代谢与营养电子杂志, 2018, 5(1): 48-52.
GONG Li-qing, WANG Yan-li, SUN Yan. Energy intake on nutritional status and quality of life in head and neck cancer patients receiving radiotherapy and chemotherapy. Electronic Journal of Metabolism and Nutrition of, 2018, 5(1): 48-52.
