Abstract：Objective To explore the effects of enteral combined parenteral nutrition treatment on the nutritional status, quality of life, chemotherapy toxicity and nosocomial infection for patients with advanced gastrointestinal cancer after two chemotherapy cycles. Methods Totally 100 patients were randomly divided into the treatment group and the control group. The treatment group (n=50) was treated with combined parenteral with enteral nutritional support and chemotherapy, the control group (n=50) was
provided with normal diet and chemotherapy. The nutritional status, toxicity reaction, quality of life, and nosocomial infection rate of the two groups were assessed and evaluated before and after each cycle of chemotherapy. Results There were no significant
differences of the nutritional status, quality of life and nosocomial infection rate between two groups before chemotherapy and after
the first cycle of chemotherapy. After two cycles of chemotherapy, the body mass index (19.59±4.05 vs 18.91±3.36, P<0.05) and
hemoglobin (109.5±7.55g/L vs 103.10±4.63g/L, P<0.05) were significantly higher than that in first cycle of chemotherapy. The
incidence of myelosuppression was significantly lower than that in control group (38.0% vs 70.0%, P<0.05). There were significant difference between nausea and vomiting in treatment group and the control group (22.0% vs 52.0%, P<0.05). The incidences of nosocomial infection in the treatment group were lower than in the control group (4.0% vs 26.0%, P<0.05). Conclusions Combined parenteral with enteral nutritional therapy after two chemotherapy cycles can not only ameliorate the nutritional status and quality of life of patients with advanced gastrointestinal cancer, but also alleviate the chemotherapy-induced adverse reaction, and prevent nosocomial infection.
李帆，李靖，田彩琴. 肠内外营养对胃肠肿瘤化疗患者营养和毒副反应的观察[J]. 肿瘤代谢与营养电子杂志, 2018, 5(1): 43-47.
1 LI Fan, 2 LI Jing, 1 TIAN Cai-qin, . Enteral and parenteral nutrition on efficacy and toxicity of chemotherapy for patients with gastrointestinal cancer. Electronic Journal of Metabolism and Nutrition of, 2018, 5(1): 43-47.
