1Sichuan Kelun Industry Group, Chengdu 610071, China; 2
Department of General Surgery / Cancer Center, Aviation General
Hospital / Beijing Institute of Translational Medicine, Chinese Academy of Sciences, Beijing 100012, China
Abstract： Lean body mass, which accounts for nearly half of the mass of the human body, participates in all human activities
and is closely relates to human health, living ability and quality. The quality of lean body tissue is closely related to the synthesis,
decomposition and metabolism of protein, and the quality of lean body tissue is regulated by many signal pathways in modern
medical research. Regulating signaling pathways of lean body mass includes positive and negative regulation, of which the former
one mainly involves in mammalian target of rapamycin pathway, transforming growth factor beta pathway, peroxisome proliferating
activated receptor co-activator pathway and G protein pathway and the latter one mainly involves in growth arrest and DNA damageinducible 45 pathway, nuclear factor kappa B pathway and myostatin pathway. In a conclusion, it will provide a guidance for the
clinical research and treatment of the skeletal muscle related disease by research on the regulating signaling pathways of lean body
mass.
